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Fibrillarin (FBL)

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FIB; FLRN; RNU3IP1; rRNA 2'-O-Methyltransferase Fibrillarin; 34 kDa nucleolar scleroderma antigen; Histone-glutamine methyltransferase

Fibrillarin (FBL)
CCC C490
HGNC 3599
MGI 95486
PubMed 10829025
RGD 1305542
UniProt P22087
Wiki Fibrillarin

Fibrillarin, also known as FBL product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing pre-ribosomal (r)RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species.
Fibrillarin is a component of several ribonucleoproteins including a nucleolar small nuclear ribonucleoprotein (SnRNP) and one of the two classes of small nucleolar ribonucleoproteins (snoRNPs). SnRNAs function in RNA splicing while snoRNPs function in ribosomal RNA processing.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC490Hu01 Recombinant Fibrillarin (FBL) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC490Hu01 Polyclonal Antibody to Fibrillarin (FBL) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Fibrillarin (FBL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fibrillarin (FBL) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Fibrillarin (FBL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Fibrillarin (FBL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fibrillarin (FBL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Fibrillarin (FBL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fibrillarin (FBL) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC490Ra01 Recombinant Fibrillarin (FBL) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC490Ra01 Polyclonal Antibody to Fibrillarin (FBL) WB,IHC
Assay Kits n/a CLIA Kit for Fibrillarin (FBL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fibrillarin (FBL) ELISA Kit Customized Service Offer
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  7. "An intact Box C sequence in the U3 snRNA is required for binding of fibrillarin, the protein common to the major family of nucleolar snRNPs."EMBO J. 10:2645-2651(1991) [PubMed] [Europe PMC] [Abstract]
  8. "The nuclear DEAD box RNA helicase p68 interacts with the nucleolar protein fibrillarin and colocalizes specifically in nascent nucleoli during telophase."Exp. Cell Res. 257:272-280(2000) [PubMed] [Europe PMC] [Abstract]
  9. "Human fibrillarin forms a sub-complex with splicing factor 2-associated p32, protein arginine methyltransferases, and tubulins alpha 3 and beta 1 that is independent of its association with preribosomal ribonucleoprotein complexes."J. Biol. Chem. 279:1607-1614(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Human 1A6/DRIM, the homolog of yeast Utp20, functions in the 18S rRNA processing."Biochim. Biophys. Acta 1773:863-868(2007) [PubMed] [Europe PMC] [Abstract]
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  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
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  16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
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  18. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  19. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  20. "Glutamine methylation in histone H2A is an RNA-polymerase-I-dedicated modification."Nature 505:564-568(2014) [PubMed] [Europe PMC] [Abstract]
  21. "The crystal structure of human fibrillarin in complex with SAH."Submitted (FEB-2009) to the PDB data bank