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Ferrochelatase (FECH)

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EPP; FCE; Protoheme Ferrolyase; Protoporphyria; Heme synthase; Protoheme ferro-lyase

Ferrochelatase (FECH)
CCC C488
HGNC 3647
MGI 95513
PubMed 7592569
RGD 1307556
UniProt P22830
Wiki Ferrochelatase

Ferrochelatase (FECH, protoheme ferrolyase) is an enzyme that catalyses the terminal (eighth) step in the biosynthesis of heme, converting protoporphyrin IX into heme. It catalyses reaction: protoporphyrin + Fe++ <=> protoheme + 2 H+. A ferrochelatase enzyme consists of 497 amino acid residues with a m.w. of 55.4 kDa.

Ferrochelatase is localized to the mitochondrion where it catalyzes the insertion of the ferrous form of iron into protoporphyrin IX in the heme synthesis pathway. Defects in ferrochelatase are associated with erythropoietic protoporphyria. Two transcript variants encoding different isoforms have been found for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC488Hu01 Recombinant Ferrochelatase (FECH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC488Hu01 Polyclonal Antibody to Ferrochelatase (FECH) WB; IHC; ICC; IP.
MAC488Hu22 Monoclonal Antibody to Ferrochelatase (FECH) WB; IHC; ICC; IP.
Assay Kits SEC488Hu ELISA Kit for Ferrochelatase (FECH) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ferrochelatase (FECH) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ferrochelatase (FECH) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ferrochelatase (FECH) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ferrochelatase (FECH) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ferrochelatase (FECH) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC488Ra01 Recombinant Ferrochelatase (FECH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC488Ra01 Polyclonal Antibody to Ferrochelatase (FECH) WB; IHC; ICC; IP.
MAC488Ra21 Monoclonal Antibody to Ferrochelatase (FECH) WB; IHC; ICC; IP.
Assay Kits SEC488Ra ELISA Kit for Ferrochelatase (FECH) Enzyme-linked immunosorbent assay for Antigen Detection.
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