≡

Endosulfine Alpha (ENSa)

[Edit]

ENS-A; ARPP-19e

Endosulfine Alpha (ENSa)
CCC C459
HGNC 3360
MGI 1891189
PubMed 24675883
RGD 62007
UniProt O43768
Wiki ENSA

Alpha-endosulfine belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes. At least eight alternatively spliced transcript variants encoding distinct isoforms have been observed.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Endosulfine Alpha (ENSa) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Endosulfine Alpha (ENSa) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Endosulfine Alpha (ENSa) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Endosulfine Alpha (ENSa) CLIA Kit Customized Service Offer
n/a ELISA Kit for Endosulfine Alpha (ENSa) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC459Mu01 Recombinant Endosulfine Alpha (ENSa) Positive Control; Immunogen; SDS-PAGE; WB.
RPC459Mu02 Recombinant Endosulfine Alpha (ENSa) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC459Mu01 Polyclonal Antibody to Endosulfine Alpha (ENSa) WB; IHC; ICC; IP.
PAC459Mu02 Polyclonal Antibody to Endosulfine Alpha (ENSa) WB; IHC; ICC; IP.
Assay Kits SEC459Mu ELISA Kit for Endosulfine Alpha (ENSa) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Endosulfine Alpha (ENSa) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Endosulfine Alpha (ENSa) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Endosulfine Alpha (ENSa) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Endosulfine Alpha (ENSa) CLIA Kit Customized Service Offer
n/a ELISA Kit for Endosulfine Alpha (ENSa) ELISA Kit Customized Service Offer
  1. "Human alpha-endosulfine, a possible regulator of sulfonylurea-sensitive K(ATP) channel: molecular cloning, expression and biological properties."Proc. Natl. Acad. Sci. U.S.A. 95:8387-8391(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Isolation, characterization, and chromosomal localization of the human ENSA gene that encodes alpha-endosulfine, a regulator of beta-cell K(ATP) channels."Diabetes 48:1873-1876(1999) [PubMed] [Europe PMC] [Abstract]
  3. "The transcribed endosulfine alpha gene is located within a type 2 diabetes-linked region on 1q: sequence and expression analysis in Pima Indians."Mol. Genet. Metab. 81:16-21(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Conformation-specific binding of alpha-synuclein to novel protein partners detected by phage display and NMR spectroscopy."J. Biol. Chem. 282:34555-34567(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Membrane-induced folding of the cAMP-regulated phosphoprotein endosulfine-alpha."Biochemistry 47:12357-12364(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]