Dipeptidase 1, Renal (DPEP1)
[Edit]RDP; MBD1; MDP; Dehydropeptidase-I; Microsomal dipeptidase; Renal dipeptidase
DPEP1 (EC 3.4.13.11) is a kidney membrane enzyme that hydrolyzes a variety of dipeptides and is implicated in renal metabolism of glutathione and its conjugates, e.g., leukotriene D4 (Kozak and Tate, 1982).
DPEP1 is responsible for hydrolysis of the beta-lactam ring of antibiotics, such as penem and carbapenem (Campbell et al., 1984). Earlier, beta-lactamase enzymes were thought to occur only in bacteria, where their probable function was in protecting the organisms against the action of beta-lactam antibiotics. These antibiotics exhibit selective toxicity against bacteria but virtual inertness against many eukaryotic cells (Adachi et al., 1990).
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPC441Hu01 | Recombinant Dipeptidase 1, Renal (DPEP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAC441Hu01 | Polyclonal Antibody to Dipeptidase 1, Renal (DPEP1) | WB; IHC; ICC; IP. |
MAC441Hu21 | Monoclonal Antibody to Dipeptidase 1, Renal (DPEP1) | WB | |
MAC441Hu22 | Monoclonal Antibody to Dipeptidase 1, Renal (DPEP1) | WB | |
Assay Kits | SEC441Hu | ELISA Kit for Dipeptidase 1, Renal (DPEP1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Dipeptidase 1, Renal (DPEP1) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Dipeptidase 1, Renal (DPEP1) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Dipeptidase 1, Renal (DPEP1) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Dipeptidase 1, Renal (DPEP1) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Dipeptidase 1, Renal (DPEP1) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Dipeptidase 1, Renal (DPEP1) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Dipeptidase 1, Renal (DPEP1) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Dipeptidase 1, Renal (DPEP1) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Dipeptidase 1, Renal (DPEP1) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Dipeptidase 1, Renal (DPEP1) | ELISA Kit Customized Service Offer |
- "Cloning and structural analysis of genomic DNA for human renal dipeptidase."Biochim. Biophys. Acta 1172:181-183(1993) [PubMed] [Europe PMC] [Abstract]
- "Primary structure of human microsomal dipeptidase deduced from molecular cloning."J. Biol. Chem. 265:3992-3995(1990) [PubMed] [Europe PMC] [Abstract]
- "Gene structural analysis and expression of human renal dipeptidase."Biotechnol. Prog. 10:134-140(1994) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Characterization of the glycosyl-phosphatidylinositol-anchored human renal dipeptidase reveals that it is more extensively glycosylated than the pig enzyme."Biochem. J. 265:429-433(1990) [PubMed] [Europe PMC] [Abstract]
- "Purification and characterization of human microsomal dipeptidase."J. Biochem. 105:957-961(1989) [PubMed] [Europe PMC] [Abstract]
- "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
- "Identification of membrane anchoring site of human renal dipeptidase and construction and expression of a cDNA for its secretory form."J. Biol. Chem. 265:15341-15345(1990) [PubMed] [Europe PMC] [Abstract]
- "Importance of Glu-125 in the catalytic activity of human renal dipeptidase."Biochim. Biophys. Acta 1163:42-48(1993) [PubMed] [Europe PMC] [Abstract]
- "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
- "Crystal structure of human renal dipeptidase involved in beta-lactam hydrolysis."J. Mol. Biol. 321:177-184(2002) [PubMed] [Europe PMC] [Abstract]
- "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]