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Dystrobrevin Alpha (DTNa)

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DTN-A; DRP3; DTN; LVNC1; Dystrophin-Related Protein 3

Dystrobrevin Alpha (DTNa)
CCC C437
HGNC 3057
MGI 106039
PubMed 9701558
UniProt Q9Y4J8
Wiki DTNA

A dystrophin-containing glycoprotein complex (DGC) links the basal lamina surrounding each muscle fibre to the fibre's cytoskeleton, providing both structural support and a scaffold for signalling molecules. Mutations in genes encoding several DGC components disrupt the complex and lead to muscular dystrophy. Dystrobrevin alpha is a protein belongs to the dystrobrevin subfamily and the dystrophin family. This protein is a component of the dystrophin-associated protein complex (DPC). The DPC consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and alpha- and beta-dystrobrevin. This protein may be involved in the formation and stability of synapses as well as the clustering of nicotinic acetylcholine receptors.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC437Hu01 Recombinant Dystrobrevin Alpha (DTNa) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Dystrobrevin Alpha (DTNa) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dystrobrevin Alpha (DTNa) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dystrobrevin Alpha (DTNa) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dystrobrevin Alpha (DTNa) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dystrobrevin Alpha (DTNa) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dystrobrevin Alpha (DTNa) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dystrobrevin Alpha (DTNa) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dystrobrevin Alpha (DTNa) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dystrobrevin Alpha (DTNa) ELISA Kit Customized Service Offer
  1. "Cloning and characterization of the human homologue of a dystrophin related phosphoprotein found at the Torpedo electric organ post-synaptic membrane."Hum. Mol. Genet. 5:489-496(1996) [PubMed] [Europe PMC] [Abstract]
  2. "The genomic organization of human dystrobrevin."Neurogenetics 1:37-42(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Characterisation of alpha-dystrobrevin in muscle."J. Cell Sci. 111:2595-2605(1998) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "DNA sequence and analysis of human chromosome 18." Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Syntrophin binds to an alternatively spliced exon of dystrophin."J. Cell Biol. 128:363-371(1995) [PubMed] [Europe PMC] [Abstract]
  8. "The three human syntrophin genes are expressed in diverse tissues, have distinct chromosomal locations, and each bind to dystrophin and its relatives."J. Biol. Chem. 271:2724-2730(1996) [PubMed] [Europe PMC] [Abstract]
  9. "Gamma1- and gamma2-syntrophins, two novel dystrophin-binding proteins localized in neuronal cells."J. Biol. Chem. 275:15851-15860(2000) [PubMed] [Europe PMC] [Abstract]
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Solution structure of the ZZ domain of dystrobrevin alpha."Submitted (JUN-2007) to the PDB data bank
  12. "Novel gene mutations in patients with left ventricular noncompaction or Barth syndrome."Circulation 103:1256-1263(2001) [PubMed] [Europe PMC] [Abstract]