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Cytoglobin is a globin molecule located in the brain and most notably utilised in marine mammals. It is thought to be a method of protection under conditions of hypoxia. The predicted function of cytoglobin is the transfer of oxygen from arterial blood to the brain.
Cytoglobin is a ubiquitously expressed hexacoordinate hemoglobin that may facilitate diffusion of oxygen through tissues, scavenge nitric oxide or other reactive oxygen species, or serve a protective function during oxidative stress (Trent and Hargrove, 2002). CYGB expression can be used as a specific marker with which hepatic stellate cells can be distinguished from portal myofibroblasts in the damaged human liver.
Cytoglobin is a ubiquitously expressed hexacoordinate hemoglobin that may facilitate diffusion of oxygen through tissues, scavenge nitric oxide or other reactive oxygen species, or serve a protective function during oxidative stress (Trent and Hargrove, 2002). CYGB expression can be used as a specific marker with which hepatic stellate cells can be distinguished from portal myofibroblasts in the damaged human liver.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC426Hu01 | Recombinant Cytoglobin (CYGB) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAC426Hu01 | Polyclonal Antibody to Cytoglobin (CYGB) | WB; IHC; ICC; IP. |
| MAC426Hu22 | Monoclonal Antibody to Cytoglobin (CYGB) | WB; IHC; ICC; IP. | |
| Assay Kits | SEC426Hu | ELISA Kit for Cytoglobin (CYGB) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Cytoglobin (CYGB) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Cytoglobin (CYGB) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Cytoglobin (CYGB) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Cytoglobin (CYGB) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Cytoglobin (CYGB) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC426Ra01 | Recombinant Cytoglobin (CYGB) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAC426Ra01 | Polyclonal Antibody to Cytoglobin (CYGB) | WB; IHC; ICC; IP. |
| MAC426Ra21 | Monoclonal Antibody to Cytoglobin (CYGB) | WB; IHC; ICC; IP. | |
| Assay Kits | SEC426Ra | ELISA Kit for Cytoglobin (CYGB) | Enzyme-linked immunosorbent assay for Antigen Detection. |
- "Cytoglobin: a novel globin type ubiquitously expressed in vertebrate tissues."Mol. Biol. Evol. 19:416-421(2002) [PubMed] [Europe PMC] [Abstract]
- "Characterization of human stellate cell activation-associated protein and its expression in human liver."Biochim. Biophys. Acta 1577:471-475(2002) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "A ubiquitously expressed human hexacoordinate hemoglobin."J. Biol. Chem. 277:19538-19545(2002) [PubMed] [Europe PMC] [Abstract]
- "Mapping protein matrix cavities in human cytoglobin through Xe atom binding."Biochem. Biophys. Res. Commun. 316:1217-1221(2004) [PubMed] [Europe PMC] [Abstract]
- "Crystal structure of cytoglobin: the fourth globin type discovered in man displays heme hexa-coordination."J. Mol. Biol. 336:917-927(2004) [PubMed] [Europe PMC] [Abstract]
- "Structural basis of human cytoglobin for ligand binding."J. Mol. Biol. 339:873-885(2004) [PubMed] [Europe PMC] [Abstract]
- "High-resolution structure of human cytoglobin: identification of extra N-and C-termini and a new dimerization mode."Acta Crystallogr. D 62:671-677(2006) [PubMed] [Europe PMC] [Abstract]