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Cubilin (CUBN)

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IFCR; MGA1; gp280; Intrinsic Factor Cobalamin Receptor; 460 kDa receptor; Intestinal intrinsic factor receptor; Intrinsic factor-vitamin B12 receptor

Cubilin (CUBN)
CCC C411
HGNC 2548
MGI 1931256
PubMed 20798259
RGD 68355
UniProt O60494
Wiki Cubilin

Cubilin (CUBN) acts as a receptor for intrinsic factor-vitamin B12 complexes. The role of receptor is supported by the presence of 27 CUB domains. Cubulin is located within the epithelium of intestine and kidney. Mutations in CUBN may play a role in autosomal recessive megaloblastic anemia.

Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands required calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC411Hu01 Recombinant Cubilin (CUBN) Positive Control; Immunogen; SDS-PAGE; WB.
RPC411Hu02 Recombinant Cubilin (CUBN) Positive Control; Immunogen; SDS-PAGE; WB.
APC411Hu02 Active Cubilin (CUBN) Cell culture; Activity Assays.
Antibodies PAC411Hu01 Polyclonal Antibody to Cubilin (CUBN) WB; IHC; ICC; IP.
MAC411Hu22 Monoclonal Antibody to Cubilin (CUBN) WB; IHC; ICC; IP.
PAC411Hu02 Polyclonal Antibody to Cubilin (CUBN) WB; IHC; ICC; IP.
Assay Kits SEC411Hu ELISA Kit for Cubilin (CUBN) Enzyme-linked immunosorbent assay for Antigen Detection.
AEC411Hu ELISA Kit for Anti-Cubilin Antibody (Anti-CUBN) Enzyme-linked immunosorbent assay for Antibody Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC411Mu01 Recombinant Cubilin (CUBN) Positive Control; Immunogen; SDS-PAGE; WB.
RPC411Mu02 Recombinant Cubilin (CUBN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC411Mu01 Polyclonal Antibody to Cubilin (CUBN) WB; IHC; ICC; IP.
PAC411Mu02 Polyclonal Antibody to Cubilin (CUBN) WB; IHC; ICC; IP.
LAC411Mu71 Biotin-Linked Polyclonal Antibody to Cubilin (CUBN) WB; IHC; ICC.
LAC411Mu81 FITC-Linked Polyclonal Antibody to Cubilin (CUBN) WB; IHC; ICC; IF.
Assay Kits SEC411Mu ELISA Kit for Cubilin (CUBN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC411Ra01 Recombinant Cubilin (CUBN) Positive Control; Immunogen; SDS-PAGE; WB.
RPC411Ra02 Recombinant Cubilin (CUBN) Positive Control; Immunogen; SDS-PAGE; WB.
RPC411Ra03 Recombinant Cubilin (CUBN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC411Ra01 Polyclonal Antibody to Cubilin (CUBN) WB; IHC; ICC; IP.
PAC411Ra02 Polyclonal Antibody to Cubilin (CUBN) WB; IHC; ICC; IP.
PAC411Ra03 Polyclonal Antibody to Cubilin (CUBN) WB; IHC; ICC; IP.
LAC411Ra71 Biotin-Linked Polyclonal Antibody to Cubilin (CUBN) WB; IHC; ICC.
Assay Kits SEC411Ra ELISA Kit for Cubilin (CUBN) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "The human intrinsic factor-vitamin B12 receptor, cubilin: molecular characterization and chromosomal mapping of the gene to 10p within the autosomal recessive megaloblastic anemia (MGA1) region."Blood 91:3593-3600(1998) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The intrinsic factor-vitamin B12 receptor, cubilin, is a high-affinity apolipoprotein A-I receptor facilitating endocytosis of high-density lipoprotein."Nat. Med. 5:656-661(1999) [PubMed] [Europe PMC] [Abstract]
  4. "Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D(3)."Proc. Natl. Acad. Sci. U.S.A. 98:13895-13900(2001) [PubMed] [Europe PMC] [Abstract]
  5. "Megalin-dependent cubilin-mediated endocytosis is a major pathway for the apical uptake of transferrin in polarized epithelia."Proc. Natl. Acad. Sci. U.S.A. 98:12491-12496(2001) [PubMed] [Europe PMC] [Abstract]
  6. "The functional cobalamin (vitamin B12)-intrinsic factor receptor is a novel complex of cubilin and amnionless."Blood 103:1573-1579(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of the ligands of protein interaction domains through a functional approach."Mol. Cell. Proteomics 6:333-345(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Structural basis for receptor recognition of vitamin-B(12)-intrinsic factor complexes."Nature 464:445-448(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Mutations in CUBN, encoding the intrinsic factor-vitamin B12 receptor, cubilin, cause hereditary megaloblastic anaemia 1."Nat. Genet. 21:309-313(1999) [PubMed] [Europe PMC] [Abstract]
  10. "Cubilin P1297L mutation associated with hereditary megaloblastic anemia 1 causes impaired recognition of intrinsic factor-vitamin B(12) by cubilin."Blood 96:405-409(2000) [PubMed] [Europe PMC] [Abstract]
  11. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
  12. "CUBN is a gene locus for albuminuria." J. Am. Soc. Nephrol. 22:555-570(2011) [PubMed] [Europe PMC] [Abstract]
  13. "Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma." Nature 469:539-542(2011) [PubMed] [Europe PMC] [Abstract]
  14. "Linkage disequilibrium analysis reveals an albuminuria risk haplotype containing three missense mutations in the cubilin gene with striking differences among European and African ancestry populations."BMC Nephrol. 13:142-142(2012) [PubMed] [Europe PMC] [Abstract]