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C-Terminal Binding Protein 1 (CTBP1)

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BARS; Brefeldin A-Ribosylated Substrate

C-Terminal Binding Protein 1 (CTBP1)
CCC C409
HGNC 2494
MGI 1201685
RGD 2441
UniProt Q13363

C-terminal-binding protein 1 is a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants. transcriptional co-repressor protein that may function in development, cell cycle regulation and cellular transformation; regulates tubulation of Golgi structures upon treatment with brefeldin A; interacts wth GTP, beta gamma subunits of G-proteins and viral EBNA3A protein

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC409Hu01 Recombinant C-Terminal Binding Protein 1 (CTBP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC409Hu01 Polyclonal Antibody to C-Terminal Binding Protein 1 (CTBP1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for C-Terminal Binding Protein 1 (CTBP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for C-Terminal Binding Protein 1 (CTBP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant C-Terminal Binding Protein 1 (CTBP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to C-Terminal Binding Protein 1 (CTBP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to C-Terminal Binding Protein 1 (CTBP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for C-Terminal Binding Protein 1 (CTBP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for C-Terminal Binding Protein 1 (CTBP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant C-Terminal Binding Protein 1 (CTBP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to C-Terminal Binding Protein 1 (CTBP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to C-Terminal Binding Protein 1 (CTBP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for C-Terminal Binding Protein 1 (CTBP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for C-Terminal Binding Protein 1 (CTBP1) ELISA Kit Customized Service Offer
  1. "Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation."Proc. Natl. Acad. Sci. U.S.A. 92:10467-10471(1995) [PubMed] [Europe PMC] [Abstract]
  2. "C-terminal binding protein is a transcriptional repressor that interacts with a specific class of vertebrate polycomb proteins."Mol. Cell. Biol. 19:777-787(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "A region in the C-terminus of adenovirus 2/5 E1a protein is required for association with a cellular phosphoprotein and important for the negative modulation of T24-ras mediated transformation, tumorigenesis and metastasis."EMBO J. 12:469-478(1993) [PubMed] [Europe PMC] [Abstract]
  6. "Interaction of EVI1 with cAMP-responsive element-binding protein-binding protein (CBP) and p300/CBP-associated factor (P/CAF) results in reversible acetylation of EVI1 and in co-localization in nuclear speckles."J. Biol. Chem. 276:44936-44943(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Physical and functional interactions between the corepressor CtBP and the Epstein-Barr virus nuclear antigen EBNA3C."J. Virol. 75:7749-7755(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Acetylation of nuclear hormone receptor-interacting protein RIP140 regulates binding of the transcriptional corepressor CtBP."Mol. Cell. Biol. 21:6181-6188(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Two nonconsensus sites in the Epstein-Barr virus oncoprotein EBNA3A cooperate to bind the co-repressor carboxyl-terminal-binding protein (CtBP)."J. Biol. Chem. 277:47197-47204(2002) [PubMed] [Europe PMC] [Abstract]
  10. "The polycomb protein Pc2 is a SUMO E3."Cell 113:127-137(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Homeodomain interacting protein kinase 2 promotes apoptosis by downregulating the transcriptional corepressor CtBP."Cell 115:177-186(2003) [PubMed] [Europe PMC] [Abstract]
  12. "Nuclear speckle-associated protein Pnn/DRS binds to the transcriptional corepressor CtBP and relieves CtBP-mediated repression of the E-cadherin gene."Mol. Cell. Biol. 24:10223-10235(2004) [PubMed] [Europe PMC] [Abstract]
  13. "Multiple domains of the receptor-interacting protein 140 contribute to transcription inhibition."Nucleic Acids Res. 32:1957-1966(2004) [PubMed] [Europe PMC] [Abstract]
  14. "Pc2-mediated sumoylation of Smad-interacting protein 1 attenuates transcriptional repression of E-cadherin."J. Biol. Chem. 280:35477-35489(2005) [PubMed] [Europe PMC] [Abstract]
  15. "Oligomerization of Evi-1 regulated by the PR domain contributes to recruitment of corepressor CtBP."Oncogene 24:6165-6173(2005) [PubMed] [Europe PMC] [Abstract]
  16. "The FoxP subclass in Xenopus laevis development."Dev. Genes Evol. 216:641-646(2006) [PubMed] [Europe PMC] [Abstract]
  17. "Zinc finger protein Wiz links G9a/GLP histone methyltransferases to the co-repressor molecule CtBP."J. Biol. Chem. 281:20120-20128(2006) [PubMed] [Europe PMC] [Abstract]
  18. "ZNF366 is an estrogen receptor corepressor that acts through CtBP and histone deacetylases."Nucleic Acids Res. 34:6126-6136(2006) [PubMed] [Europe PMC] [Abstract]
  19. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  20. "CtBP is an essential corepressor for BCL6 autoregulation."Mol. Cell. Biol. 28:2175-2186(2008) [PubMed] [Europe PMC] [Abstract]
  21. "Acetylation-dependent interaction of SATB1 and CtBP1 mediates transcriptional repression by SATB1."Mol. Cell. Biol. 29:1321-1337(2009) [PubMed] [Europe PMC] [Abstract]
  22. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  23. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  24. "Transcription corepressor CtBP is an NAD(+)-regulated dehydrogenase."Mol. Cell 10:857-869(2002) [PubMed] [Europe PMC] [Abstract]