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Crystallin Alpha A (CRYaA)

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CRY-AA; CRYA-A; CRYA1; HSPB4; Heat shock protein beta-4

Crystallin Alpha A (CRYaA)
CCC C408
HGNC 2388
MGI 88515
PubMed 10627817
RGD 2413
UniProt P02489
Wiki CRYAA

Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC408Hu01 Recombinant Crystallin Alpha A (CRYaA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Crystallin Alpha A (CRYaA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Crystallin Alpha A (CRYaA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Crystallin Alpha A (CRYaA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Crystallin Alpha A (CRYaA) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC408Mu01 Recombinant Crystallin Alpha A (CRYaA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Crystallin Alpha A (CRYaA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Crystallin Alpha A (CRYaA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Crystallin Alpha A (CRYaA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Crystallin Alpha A (CRYaA) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Crystallin Alpha A (CRYaA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Crystallin Alpha A (CRYaA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Crystallin Alpha A (CRYaA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Crystallin Alpha A (CRYaA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Crystallin Alpha A (CRYaA) ELISA Kit Customized Service Offer
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  2. "A reassessment of mammalian alpha A-crystallin sequences using DNA sequencing: implications for anthropoid affinities of tarsier."J. Mol. Evol. 41:901-908(1995) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning, expression, and chaperone-like activity of human alphaA-crystallin."J. Biol. Chem. 271:31973-31980(1996) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence of human chromosome 21." Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "A pseudo-exon in the functional human alpha A-crystallin gene."Nature 337:752-754(1989) [PubMed] [Europe PMC] [Abstract]
  7. "Isolation and partial characterization of the human alpha A-crystallin gene."Exp. Eye Res. 43:285-291(1986) [PubMed] [Europe PMC] [Abstract]
  8. "Sequence analysis of betaA3, betaB3, and betaA4 crystallins completes the identification of the major proteins in young human lens."J. Biol. Chem. 272:2268-2275(1997) [PubMed] [Europe PMC] [Abstract]
  9. "Vertebrate lens alpha-crystallins are modified by O-linked N-acetylglucosamine."J. Biol. Chem. 267:555-563(1992) [PubMed] [Europe PMC] [Abstract]
  10. "Post-translational modifications of water-soluble human lens crystallins from young adults."J. Biol. Chem. 269:12494-12502(1994) [PubMed] [Europe PMC] [Abstract]
  11. "Differential phosphorylation of alpha-A crystallin in human lens of different age."Exp. Eye Res. 62:499-504(1996) [PubMed] [Europe PMC] [Abstract]
  12. "Modifications of the water-insoluble human lens alpha-crystallins."Exp. Eye Res. 63:661-672(1996) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitation of asparagine-101 deamidation from alpha-A crystallin during aging of the human lens."Curr. Eye Res. 17:247-250(1998) [PubMed] [Europe PMC] [Abstract]
  14. "In vivo acetylation identified at lysine 70 of human lens alphaA-crystallin."Protein Sci. 7:1451-1457(1998) [PubMed] [Europe PMC] [Abstract]
  15. "The major in vivo modifications of the human water-insoluble lens crystallins are disulfide bonds, deamidation, methionine oxidation and backbone cleavage."Exp. Eye Res. 71:195-207(2000) [PubMed] [Europe PMC] [Abstract]
  16. "Chaperone-like activity of alpha-crystallin and other small heat shock proteins."Curr. Protein Pept. Sci. 2:205-225(2001) [PubMed] [Europe PMC] [Abstract]
  17. "Enhanced C-terminal truncation of alphaA- and alphaB-crystallins in diabetic lenses."Invest. Ophthalmol. Vis. Sci. 43:3265-3272(2002) [PubMed] [Europe PMC] [Abstract]
  18. "Structural and functional roles of deamidation and/or truncation of N- or C-termini in human alpha A-crystallin."Biochemistry 47:10069-10083(2008) [PubMed] [Europe PMC] [Abstract]
  19. "C-Terminal truncation affects subunit exchange of human alphaA-crystallin with alphaB-crystallin."Mol. Cell. Biochem. 308:85-91(2008) [PubMed] [Europe PMC] [Abstract]
  20. "HSPB7 is a SC35 speckle resident small heat shock protein."Biochim. Biophys. Acta 1793:1343-1353(2009) [PubMed] [Europe PMC] [Abstract]
  21. "Importance of eye lens alpha-crystallin heteropolymer with 3:1 alphaA to alphaB ratio: stability, aggregation, and modifications."IUBMB Life 62:693-702(2010) [PubMed] [Europe PMC] [Abstract]
  22. "Acetylation of alphaA-crystallin in the human lens: effects on structure and chaperone function."Biochim. Biophys. Acta 1822:120-129(2012) [PubMed] [Europe PMC] [Abstract]
  23. "Identification of histidine residues involved in Zn(2+) binding to alphaA- and alphaB-Crystallin by chemical modification and MALDI TOF mass spectrometry."Protein J. 31:623-640(2012) [PubMed] [Europe PMC] [Abstract]
  24. "Autosomal dominant congenital cataract associated with a missense mutation in the human alpha crystallin gene CRYAA."Hum. Mol. Genet. 7:471-474(1998) [PubMed] [Europe PMC] [Abstract]
  25. "Structural and functional changes in the alpha A-crystallin R116C mutant in hereditary cataracts."Biochemistry 39:15791-15798(2000) [PubMed] [Europe PMC] [Abstract]
  26. "Cell death triggered by a novel mutation in the alphaA-crystallin gene underlies autosomal dominant cataract linked to chromosome 21q."Eur. J. Hum. Genet. 11:784-793(2003) [PubMed] [Europe PMC] [Abstract]
  27. "Congenital cataract and macular hypoplasia in humans associated with a de novo mutation in CRYAA and compound heterozygous mutations in P."Graefes Arch. Clin. Exp. Ophthalmol. 244:912-919(2006) [PubMed] [Europe PMC] [Abstract]
  28. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
  29. "Clinical variability of autosomal dominant cataract, microcornea and corneal opacity and novel mutation in the alpha A crystallin gene (CRYAA)."Am. J. Med. Genet. A 146:833-842(2008) [PubMed] [Europe PMC] [Abstract]
  30. "A novel mutation in AlphaA-crystallin (CRYAA) caused autosomal dominant congenital cataract in a large Chinese family."Hum. Mutat. 29:769-769(2008) [PubMed] [Europe PMC] [Abstract]
  31. "Whole exome sequencing in dominant cataract identifies a new causative factor, CRYBA2, and a variety of novel alleles in known genes."Hum. Genet. 132:761-770(2013) [PubMed] [Europe PMC] [Abstract]