≡

Centrosomal Protein 110kDa (CEP110)

[Edit]

FAN; CP110; CEP1; Centriolin; Centrosomal Protein 1

Centrosomal Protein 110kDa (CEP110)
CCC C373
HGNC 1858
MGI 1889576
PubMed 11956314
RGD 1305317
UniProt Q7Z7A1
Wiki CEP110

Centriolin is a centrosomal protein required for the centrosome to function as a microtubule organizing center. The gene product is also associated with centrosome maturation. One version of stem cell myeloproliferative disorder is the result of a reciprocal translocation between chromosomes 8 and 9, with the breakpoint associated with fibroblast growth factor receptor 1 and centrosomal protein 1. A chromosomal aberration involving CEP110 may be a cause of stem cell myeloproliferative disorder (MPD). MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion protein CEP110-FGFR1 is found in the cytoplasm, exhibits constitutive kinase activity and may be responsible for the transforming activity.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC373Hu01 Recombinant Centrosomal Protein 110kDa (CEP110) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC373Hu01 Polyclonal Antibody to Centrosomal Protein 110kDa (CEP110) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Centrosomal Protein 110kDa (CEP110) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centrosomal Protein 110kDa (CEP110) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Centrosomal Protein 110kDa (CEP110) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Centrosomal Protein 110kDa (CEP110) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centrosomal Protein 110kDa (CEP110) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centrosomal Protein 110kDa (CEP110) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centrosomal Protein 110kDa (CEP110) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Centrosomal Protein 110kDa (CEP110) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Centrosomal Protein 110kDa (CEP110) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centrosomal Protein 110kDa (CEP110) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centrosomal Protein 110kDa (CEP110) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centrosomal Protein 110kDa (CEP110) ELISA Kit Customized Service Offer
  1. "FGFR1 is fused to the centrosome-associated protein CEP110 in the 8p12 stem cell myeloproliferative disorder with t(8;9)(p12;q33)."Blood 95:1788-1796(2000) [PubMed] [Europe PMC] [Abstract]
  2. "A novel human protein of the maternal centriole is required for the final stages of cytokinesis and entry into S phase."J. Cell Biol. 161:535-545(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Humoral detection of leukaemia-associated antigens in presentation acute myeloid leukaemia."Biochem. Biophys. Res. Commun. 335:1293-1304(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones."DNA Res. 10:49-57(2003) [PubMed] [Europe PMC] [Abstract]
  8. "CEP110 and ninein are located in a specific domain of the centrosome associated with centrosome maturation."J. Cell Sci. 115:1825-1835(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Centriolin anchoring of exocyst and SNARE complexes at the midbody is required for secretory-vesicle-mediated abscission."Cell 123:75-87(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Hook2 localizes to the centrosome, binds directly to centriolin/CEP110 and contributes to centrosomal function."Traffic 8:32-46(2007) [PubMed] [Europe PMC] [Abstract]