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Corneodesmosin (CDSN)

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HTSS; S protein

Corneodesmosin (CDSN)
CCC C369
HGNC 1802
MGI 3505689
PubMed 21628128
RGD 1598543
UniProt Q15517
Wiki Corneodesmosin

Corneodesmosin is a protein found in corneodesmosomes, which localize to human epidermis and other cornified squamous epithelia. During maturation of the cornified layers, the protein undergoes a series of cleavages, which are thought to be required for desquamation. The gene is located in the major histocompatibility complex (MHC) class I region on chromosome 6.

Corneodesmosomes are intercellular structures that are involved in desquamation, the shedding of superficial corneocytes from the skin surface. Corneocytes are anucleated cells derived from keratinocytes during the late stages of terminal differentiation of cornified squamous epithelia such as the epidermis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC369Hu01 Recombinant Corneodesmosin (CDSN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC369Hu01 Polyclonal Antibody to Corneodesmosin (CDSN) WB; IHC; ICC; IP.
MAC369Hu22 Monoclonal Antibody to Corneodesmosin (CDSN) WB; IHC; ICC; IP.
Assay Kits SEC369Hu ELISA Kit for Corneodesmosin (CDSN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Corneodesmosin (CDSN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Corneodesmosin (CDSN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Corneodesmosin (CDSN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Corneodesmosin (CDSN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Corneodesmosin (CDSN) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Corneodesmosin (CDSN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Corneodesmosin (CDSN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Corneodesmosin (CDSN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Corneodesmosin (CDSN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Corneodesmosin (CDSN) ELISA Kit Customized Service Offer
  1. "Identification in the HLA class I region of a gene expressed late in keratinocyte differentiation."Proc. Natl. Acad. Sci. U.S.A. 90:9470-9474(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Expression cloning of human corneodesmosin proves its identity with the product of the S gene and allows improved characterization of its processing during keratinocyte differentiation."J. Biol. Chem. 273:22640-22647(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Corneodesmosin DNA polymorphisms in MHC haplotypes and Japanese patients with psoriasis."Tissue Antigens 60:77-83(2002) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of six novel polymorphisms in the human corneodesmosin gene."Tissue Antigens 57:32-38(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Corneodesmosin gene polymorphism demonstrates strong linkage disequilibrium with HLA and association with psoriasis vulgaris."Tissue Antigens 54:439-449(1999) [PubMed] [Europe PMC] [Abstract]
  8. "Characterization and purification of human corneodesmosin, an epidermal basic glycoprotein associated with corneocyte-specific modified desmosomes."J. Biol. Chem. 272:31770-31776(1997) [PubMed] [Europe PMC] [Abstract]
  9. "Hypotrichosis simplex of the scalp is associated with nonsense mutations in CDSN encoding corneodesmosin."Nat. Genet. 34:151-153(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Loss of corneodesmosin leads to severe skin barrier defect, pruritus, and atopy: unraveling the peeling skin disease."Am. J. Hum. Genet. 87:274-281(2010) [PubMed] [Europe PMC] [Abstract]
  11. "S gene (Corneodesmosin) diversity and its relationship to psoriasis; high content of cSNP in the HLA-linked S gene."J. Invest. Dermatol. 114:1158-1163(2000) [PubMed] [Europe PMC] [Abstract]
  12. "Psoriasis is associated with a SNP haplotype of the corneodesmosin gene (CDSN)."Tissue Antigens 60:292-298(2002) [PubMed] [Europe PMC] [Abstract]