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Carbonyl Reductase 1 (CBR1)

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CBR; SDR21C1; CRN; Short Chain Dehydrogenase/Reductase Family 21C,Member 1; 15-hydroxyprostaglandin dehydrogenase [NADP(+)]; Prostaglandin 9-ketoreductase

Carbonyl Reductase 1 (CBR1)
CCC C362
HGNC 1548
MGI 88284
PubMed 23995085
RGD 2286
UniProt P16152
Wiki CBR1

Carbonyl reductase is one of several monomeric, NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds. This enzyme is widely distributed in human tissues. Another carbonyl reductase gene, CRB3, lies close to this gene on chromosome 21q. CBR1 metabolizes many toxic environmental quinones and pharmacological relevant substrates such as the anticancer doxorubicin.Up-to-date two non-synonymous polymorphisms on CBR1 have been identified. The CBR1 V88I polymorphism encodes for a valine-to-isoleucin substitution at position 88 of the aminoacid chain. In vitro studies with recombinant proteins indicate that the CBR1 V88 isoform has a higher Vmax towards the substrates menadione (vitamin K3) and daunorubicin.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC362Hu01 Recombinant Carbonyl Reductase 1 (CBR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC362Hu01 Polyclonal Antibody to Carbonyl Reductase 1 (CBR1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Carbonyl Reductase 1 (CBR1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Carbonyl Reductase 1 (CBR1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC362Mu01 Recombinant Carbonyl Reductase 1 (CBR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC362Mu01 Polyclonal Antibody to Carbonyl Reductase 1 (CBR1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Carbonyl Reductase 1 (CBR1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Carbonyl Reductase 1 (CBR1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC362Ra01 Recombinant Carbonyl Reductase 1 (CBR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC362Ra01 Polyclonal Antibody to Carbonyl Reductase 1 (CBR1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Carbonyl Reductase 1 (CBR1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Carbonyl Reductase 1 (CBR1) ELISA Kit Customized Service Offer
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  9. "Inhibition of polymorphic human carbonyl reductase 1 (CBR1) by the cardioprotectant flavonoid 7-monohydroxyethyl rutoside (monoHER)."Pharm. Res. 25:1730-1734(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "An unbiased cell morphology-based screen for new, biologically active small molecules."PLoS Biol. 3:E128-E128(2005) [PubMed] [Europe PMC] [Abstract]
  13. "Glutathione traps formaldehyde by formation of a bicyclo[4.4.1]undecane adduct."Org. Biomol. Chem. 5:3363-3367(2007) [PubMed] [Europe PMC] [Abstract]
  14. "Human carbonyl reductase 1 is an S-nitrosoglutathione reductase."J. Biol. Chem. 283:35756-35762(2008) [PubMed] [Europe PMC] [Abstract]
  15. "A functional genetic polymorphism on human carbonyl reductase 1 (CBR1 V88I) impacts on catalytic activity and NADPH binding affinity."Drug Metab. Dispos. 35:973-980(2007) [PubMed] [Europe PMC] [Abstract]