Caspase 6 (CASP6)

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MCH2; Cysteinyl Aspartate Specific Proteinases 6; Caspase 6,Apoptosis-Related Cysteine Peptidase; Apoptotic protease Mch-2

Caspase 6 (CASP6)
Caspase-6 have been identified in numerous mammals for which complete genome data are available. Unique orthologs are also present in birds, lizards, lissamphibians, and teleosts. This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in two transcript variants that encode different isoforms.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC340Hu01 Recombinant Caspase 6 (CASP6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC340Hu01 Polyclonal Antibody to Caspase 6 (CASP6) WB; IHC; ICC; IP.
MAC340Hu22 Monoclonal Antibody to Caspase 6 (CASP6) WB; IHC; ICC; IP.
LAC340Hu71 Biotin-Linked Polyclonal Antibody to Caspase 6 (CASP6) WB; IHC; ICC.
LAC340Hu81 FITC-Linked Polyclonal Antibody to Caspase 6 (CASP6) WB; IHC; ICC; IF.
MAC340Hu21 Monoclonal Antibody to Caspase 6 (CASP6) WB; IHC; ICC; IP.
MAC340Hu23 Monoclonal Antibody to Caspase 6 (CASP6) WB; IHC; ICC; IP.
MAC340Hu24 Monoclonal Antibody to Caspase 6 (CASP6) WB; IHC; ICC; IP.
MAC340Hu25 Monoclonal Antibody to Caspase 6 (CASP6) WB; IHC; ICC; IP.
MAC340Hu29 Monoclonal Antibody to Caspase 6 (CASP6) WB; IHC; ICC; IP.
MAC340Hu27 Monoclonal Antibody to Caspase 6 (CASP6) WB; IHC; ICC; IP.
Assay Kits SEC340Hu ELISA Kit for Caspase 6 (CASP6) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Caspase 6 (CASP6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Caspase 6 (CASP6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Caspase 6 (CASP6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Caspase 6 (CASP6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Caspase 6 (CASP6) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Caspase 6 (CASP6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Caspase 6 (CASP6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Caspase 6 (CASP6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Caspase 6 (CASP6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Caspase 6 (CASP6) ELISA Kit Customized Service Offer

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC340Bo01 Recombinant Caspase 6 (CASP6) Positive Control; Immunogen; SDS-PAGE; WB.
RPC340Bo02 Recombinant Caspase 6 (CASP6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC340Bo02 Polyclonal Antibody to Caspase 6 (CASP6) WB; IHC; ICC; IP.
PAC340Bo01 Polyclonal Antibody to Caspase 6 (CASP6) WB; IHC; ICC; IP.
MAC340Bo22 Monoclonal Antibody to Caspase 6 (CASP6) WB; IHC
LAC340Bo71 Biotin-Linked Polyclonal Antibody to Caspase 6 (CASP6) WB; IHC; ICC.
MAC340Bo21 Monoclonal Antibody to Caspase 6 (CASP6) WB
MAC340Bo23 Monoclonal Antibody to Caspase 6 (CASP6) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Caspase 6 (CASP6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Caspase 6 (CASP6) ELISA Kit Customized Service Offer
  1. "Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family."Cancer Res. 55:2737-2742(1995) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32."J. Biol. Chem. 271:27099-27106(1996) [PubMed] [Europe PMC] [Abstract]
  4. "Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase."Mol. Cell 14:801-811(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Regulation of caspase-6 and FLIP by the AMPK family member ARK5."Oncogene 23:7067-7075(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]