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Bcl2 Antagonist/Killer 1 (BAK1)

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BAK; BAK-LIKE; BCL2L7; CDN1; Bcl-2 Homologous Antagonist/Killer; Apoptosis regulator BAK; Bcl-2-like protein 7

Bcl2 Antagonist/Killer 1 (BAK1)
CCC C324
HGNC 949
MGI 1097161
PubMed 20561260
RGD 621635
UniProt Q16611
Wiki BAK1
Bcl-2 homologous antagonist/killer is a protein belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress.Recently, one study of the role of genetics in abdominal aortic aneurism (AAA) showed that different BAK1 variants can exist in both diseased and nondiseased AA tissues compared to matching blood samples.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC324Hu01 Recombinant Bcl2 Antagonist/Killer 1 (BAK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC324Hu01 Polyclonal Antibody to Bcl2 Antagonist/Killer 1 (BAK1) WB; IHC; ICC; IP.
MAC324Hu22 Monoclonal Antibody to Bcl2 Antagonist/Killer 1 (BAK1) WB; IHC; ICC; IP.
Assay Kits SEC324Hu ELISA Kit for Bcl2 Antagonist/Killer 1 (BAK1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Bcl2 Antagonist/Killer 1 (BAK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Bcl2 Antagonist/Killer 1 (BAK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Bcl2 Antagonist/Killer 1 (BAK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Bcl2 Antagonist/Killer 1 (BAK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Bcl2 Antagonist/Killer 1 (BAK1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Bcl2 Antagonist/Killer 1 (BAK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Bcl2 Antagonist/Killer 1 (BAK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Bcl2 Antagonist/Killer 1 (BAK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Bcl2 Antagonist/Killer 1 (BAK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Bcl2 Antagonist/Killer 1 (BAK1) ELISA Kit Customized Service Offer
  1. "Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K."Nature 374:731-733(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Induction of apoptosis by the Bcl-2 homologue Bak."Nature 374:733-736(1995) [PubMed] [Europe PMC] [Abstract]
  3. "Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak."Nature 374:736-739(1995) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions."EMBO J. 14:5589-5596(1995) [PubMed] [Europe PMC] [Abstract]
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "Human Bop is a novel BH3-only member of the Bcl-2 protein family."Protein Cell 3:790-801(2012) [PubMed] [Europe PMC] [Abstract]
  10. "Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis."Science 275:983-986(1997) [PubMed] [Europe PMC] [Abstract]
  11. "The X-ray structure of a BAK homodimer reveals an inhibitory zinc binding site."Mol. Cell 24:677-688(2006) [PubMed] [Europe PMC] [Abstract]
  12. "A structural viral mimic of prosurvival Bcl-2: a pivotal role for sequestering proapoptotic Bax and Bak."Mol. Cell 25:933-942(2007) [PubMed] [Europe PMC] [Abstract]
  13. "Crystal structure of MS0836."Submitted (APR-2008) to the PDB data bank