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Activating Transcription Factor 3 (ATF3)

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Cyclic AMP-dependent Transcription Factor ATF3

Activating Transcription Factor 3 (ATF3)
CCC C303
HGNC 785
MGI 109384
PubMed 10440233
RGD 2165
UniProt P18847
Wiki ATF3
Activating transcription factor 3 is a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors.
Multiple transcript variants encoding two different isoforms have been found for this gene. The longer isoform represses rather than activates transcription from promoters with ATF binding elements. The shorter isoform (deltaZip2) lacks the leucine zipper protein-dimerization motif and does not bind to DNA, and it stimulates transcription presumably by sequestering inhibitory co-factors away from the promoter. It is possible that alternative splicing of the ATF3 gene may be physiologically important in the regulation of target genes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC303Hu01 Recombinant Activating Transcription Factor 3 (ATF3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC303Hu01 Polyclonal Antibody to Activating Transcription Factor 3 (ATF3) WB; IHC; ICC; IP.
MAC303Hu21 Monoclonal Antibody to Activating Transcription Factor 3 (ATF3) WB; IHC; ICC; IP.
Assay Kits SEC303Hu ELISA Kit for Activating Transcription Factor 3 (ATF3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC303Mu01 Recombinant Activating Transcription Factor 3 (ATF3) Positive Control; Immunogen; SDS-PAGE; WB.
RPC303Mu02 Recombinant Activating Transcription Factor 3 (ATF3) Positive Control; Immunogen; SDS-PAGE; WB.
APC303Mu01 Active Activating Transcription Factor 3 (ATF3) Cell culture; Activity Assays.
Antibodies PAC303Mu01 Polyclonal Antibody to Activating Transcription Factor 3 (ATF3) WB; IHC; ICC; IP.
PAC303Mu02 Polyclonal Antibody to Activating Transcription Factor 3 (ATF3) WB; IHC; ICC; IP.
Assay Kits SEC303Mu ELISA Kit for Activating Transcription Factor 3 (ATF3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Activating Transcription Factor 3 (ATF3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Activating Transcription Factor 3 (ATF3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Activating Transcription Factor 3 (ATF3) Polyclonal Antibody Customized Service Offer
Assay Kits SEC303Ra ELISA Kit for Activating Transcription Factor 3 (ATF3) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "ATF3 and ATF3 delta Zip. Transcriptional repression versus activation by alternatively spliced isoforms."J. Biol. Chem. 269:15819-15826(1994) [PubMed] [Europe PMC] [Abstract]
  2. "An alternatively spliced isoform of transcriptional repressor ATF3 and its induction by stress stimuli."Nucleic Acids Res. 30:2398-2406(2002) [PubMed] [Europe PMC] [Abstract]
  3. "Amino acid deprivation and endoplasmic reticulum stress induce expression of multiple activating transcription factor-3 mRNA species that, when overexpressed in HepG2 cells, modulate transcription by the human asparagine synthetase promoter."J. Biol. Chem. 278:38402-38412(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers."Genes Dev. 3:2083-2090(1989) [PubMed] [Europe PMC] [Abstract]
  8. ErratumGenes Dev. 4:682-682(1990)
  9. "An unappreciated role for RNA surveillance."Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]