Angiomotin (AMOT)
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Angiomotin belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. The encoded protein is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels. Alternatively spliced transcript variants encoding different isoforms have been described, but their full-length nature has not been completely determined. Angiomotin is a 675-residue protein that increases the random migration of endothelial cells as well as the migration of endothelial cells toward growth factors.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC296Hu01 | Recombinant Angiomotin (AMOT) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPC296Hu02 | Recombinant Angiomotin (AMOT) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| RPC296Hu03 | Recombinant Angiomotin (AMOT) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAC296Hu01 | Polyclonal Antibody to Angiomotin (AMOT) | WB; IHC; ICC; IP. |
| MAC296Hu21 | Monoclonal Antibody to Angiomotin (AMOT) | WB; IHC; ICC; IP. | |
| PAC296Hu02 | Polyclonal Antibody to Angiomotin (AMOT) | WB; IHC; ICC; IP. | |
| MAC296Hu23 | Monoclonal Antibody to Angiomotin (AMOT) | WB; IHC; ICC; IP. | |
| MAC296Hu24 | Monoclonal Antibody to Angiomotin (AMOT) | WB; IHC; ICC; IP. | |
| MAC296Hu25 | Monoclonal Antibody to Angiomotin (AMOT) | WB; IHC; ICC; IP. | |
| MAC296Hu22 | Monoclonal Antibody to Angiomotin (AMOT) | WB; IHC; ICC; IP. | |
| Assay Kits | SEC296Hu | ELISA Kit for Angiomotin (AMOT) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Angiomotin (AMOT) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Angiomotin (AMOT) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Angiomotin (AMOT) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Angiomotin (AMOT) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Angiomotin (AMOT) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Angiomotin (AMOT) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Angiomotin (AMOT) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Angiomotin (AMOT) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Angiomotin (AMOT) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Angiomotin (AMOT) | ELISA Kit Customized Service Offer |
- "Angiomotin. An angiostatin binding protein that regulates endothelial cell migration and tube formation."J. Cell Biol. 152:1247-1254(2001) [PubMed] [Europe PMC] [Abstract]
- "Angiomotin regulates endothelial cell-cell junctions and cell motility."J. Biol. Chem. 280:34859-34869(2005) [PubMed] [Europe PMC] [Abstract]
- "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
- "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells."Cell 125:535-548(2006) [PubMed] [Europe PMC] [Abstract]
- "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
- "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
- "The Nedd4-like ubiquitin E3 ligases target angiomotin/p130 to ubiquitin-dependent degradation."Biochem. J. 444:279-289(2012) [PubMed] [Europe PMC] [Abstract]