5-Hydroxytryptamine Receptor 1A (HTR1A)
[Edit]5HTR1A; 5HTR1-A; 5-HTR1-A; ADRB2RL1; ADRBRL1; Serotonin Receptor 1A
The receptor is a subtype of 5-HT receptor that binds the endogenous neurotransmitter serotonin (5-hydroxtryptamine, 5-HT). It is a G protein-coupled receptor (GPCR) that is coupled to Gi/Go and mediates inhibitory neurotransmission. HTR1A denotes the human gene encoding for the receptor. The 5-HT1A receptor is the most widespread of all the 5-HT receptors. In the central nervous system, 5-HT1A receptors exist in the cerebral cortex, hippocampus, septum, amygdala, and raphe nucelus in high densities, while low amounts also exist in the basal ganglia and thalamus. The 5-HT1A receptors in the raphe nucleus are largely somatodendritic autoreceptors. The decreases in 5-HT-1A receptor densities correlated with decreased glucose utilization as measured by PET scan.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPC271Hu01 | Recombinant 5-Hydroxytryptamine Receptor 1A (HTR1A) | Positive Control; Immunogen; SDS-PAGE; WB. |
RPC271Hu02 | Recombinant 5-Hydroxytryptamine Receptor 1A (HTR1A) | Positive Control; Immunogen; SDS-PAGE; WB. | |
Antibodies | PAC271Hu01 | Polyclonal Antibody to 5-Hydroxytryptamine Receptor 1A (HTR1A) | WB; IHC; ICC; IP. |
MAC271Hu21 | Monoclonal Antibody to 5-Hydroxytryptamine Receptor 1A (HTR1A) | WB; IHC; ICC; IP. | |
PAC271Hu02 | Polyclonal Antibody to 5-Hydroxytryptamine Receptor 1A (HTR1A) | WB; IHC; ICC; IP. | |
Assay Kits | SEC271Hu | ELISA Kit for 5-Hydroxytryptamine Receptor 1A (HTR1A) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant 5-Hydroxytryptamine Receptor 1A (HTR1A) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to 5-Hydroxytryptamine Receptor 1A (HTR1A) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to 5-Hydroxytryptamine Receptor 1A (HTR1A) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for 5-Hydroxytryptamine Receptor 1A (HTR1A) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for 5-Hydroxytryptamine Receptor 1A (HTR1A) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant 5-Hydroxytryptamine Receptor 1A (HTR1A) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to 5-Hydroxytryptamine Receptor 1A (HTR1A) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to 5-Hydroxytryptamine Receptor 1A (HTR1A) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for 5-Hydroxytryptamine Receptor 1A (HTR1A) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for 5-Hydroxytryptamine Receptor 1A (HTR1A) | ELISA Kit Customized Service Offer |
- "An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins."Nature 329:75-79(1987) [PubMed] [Europe PMC] [Abstract]
- "Human-specific amino acid changes found in 103 protein-coding genes."Mol. Biol. Evol. 21:936-944(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "A polymerase chain reaction mediated by a single primer: cloning of genomic sequences adjacent to a serotonin receptor protein coding region."Nucleic Acids Res. 19:7155-7160(1991) [PubMed] [Europe PMC] [Abstract]
- "Expression of 5HT1a receptors on activated human T cells. Regulation of cyclic AMP levels and T cell proliferation by 5-hydroxytryptamine."J. Immunol. 151:1175-1183(1993) [PubMed] [Europe PMC] [Abstract]
- "The genomic clone G-21 which resembles a beta-adrenergic receptor sequence encodes the 5-HT1A receptor."Nature 335:358-360(1988) [PubMed] [Europe PMC] [Abstract]
- "Agonist-induced desensitization and loss of high-affinity binding sites of stably expressed human 5-HT1A receptors."J. Pharmacol. Exp. Ther. 268:1098-1106(1994) [PubMed] [Europe PMC] [Abstract]
- "The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells."J. Proteome Res. 6:298-305(2007) [PubMed] [Europe PMC] [Abstract]
- "Serotonin receptors."Chem. Rev. 108:1614-1641(2008) [PubMed] [Europe PMC] [Abstract]
- "5-HT1A receptor-regulated signal transduction pathways in brain."Cell. Signal. 22:1406-1412(2010) [PubMed] [Europe PMC] [Abstract]
- "Serotonin receptors - from molecular biology to clinical applications."Physiol. Res. 60:15-25(2011) [PubMed] [Europe PMC] [Abstract]
- "Menstrual cycle-dependent febrile episode mediated by sequence-specific repression of poly(ADP-ribose) polymerase-1 on the transcription of the human serotonin receptor 1A gene."Hum. Mutat. 33:209-217(2012) [PubMed] [Europe PMC] [Abstract]
- "Role of glycosphingolipids in the function of human serotonin(1)A receptors."J. Neurochem. 123:716-724(2012) [PubMed] [Europe PMC] [Abstract]
- "Post-synaptic density-95 (PSD-95) binding capacity of G-protein-coupled receptor 30 (GPR30), an estrogen receptor that can be identified in hippocampal dendritic spines."J. Biol. Chem. 288:6438-6450(2013) [PubMed] [Europe PMC] [Abstract]
- "Two naturally occurring amino acid substitutions in the human 5-HT1A receptor: glycine 22 to serine 22 and isoleucine 28 to valine 28."Biochem. Biophys. Res. Commun. 210:530-536(1995) [PubMed] [Europe PMC] [Abstract]
- "Novel mutations in the promoter and coding region of the human 5-HT1A receptor gene and association analysis in schizophrenia."Am. J. Med. Genet. 81:434-439(1998) [PubMed] [Europe PMC] [Abstract]