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Nuclear Receptor Subfamily 0,Group B,Member 2 (NR0B2)

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SHP; SHP1; Small Heterodimer Partner; Orphan nuclear receptor SHP

Nuclear Receptor Subfamily 0,Group B,Member 2 (NR0B2)
CCC C266
HGNC 7961
MGI 1346344
PubMed 18537191
RGD 621032
UniProt Q15466
Wiki SHP

The small heterodimer partner (SHP) protein is a member of the nuclear receptor family of intracellular transcription factors and is encoded by the NR0B2 gene. SHP is unusual for a nuclear receptor in that it lacks a DNA binding domain. Therefore technically it is neither a transcription factor nor nuclear receptor but nevertheless it is still classified as such due to relatively high sequence homology with other nuclear receptor family members.

The main function of SHP appears to be repression of other nuclear receptors through association to produce a non-productive heterodimer. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC266Hu01 Recombinant Nuclear Receptor Subfamily 0,Group B,Member 2 (NR0B2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC266Hu01 Polyclonal Antibody to Nuclear Receptor Subfamily 0,Group B,Member 2 (NR0B2) WB; IHC; ICC; IP.
MAC266Hu21 Monoclonal Antibody to Nuclear Receptor Subfamily 0,Group B,Member 2 (NR0B2) WB; IHC; ICC; IP.
Assay Kits SEC266Hu ELISA Kit for Nuclear Receptor Subfamily 0,Group B,Member 2 (NR0B2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nuclear Receptor Subfamily 0,Group B,Member 2 (NR0B2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nuclear Receptor Subfamily 0,Group B,Member 2 (NR0B2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nuclear Receptor Subfamily 0,Group B,Member 2 (NR0B2) Polyclonal Antibody Customized Service Offer
Assay Kits SEC266Mu ELISA Kit for Nuclear Receptor Subfamily 0,Group B,Member 2 (NR0B2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC266Ra01 Recombinant Nuclear Receptor Subfamily 0,Group B,Member 2 (NR0B2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC266Ra01 Polyclonal Antibody to Nuclear Receptor Subfamily 0,Group B,Member 2 (NR0B2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Nuclear Receptor Subfamily 0,Group B,Member 2 (NR0B2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nuclear Receptor Subfamily 0,Group B,Member 2 (NR0B2) ELISA Kit Customized Service Offer
  1. "An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors."Science 272:1336-1339(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Structure and expression of the orphan nuclear receptor SHP gene."J. Biol. Chem. 273:14398-14402(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Mutations in the small heterodimer partner gene are associated with mild obesity in Japanese subjects." Proc. Natl. Acad. Sci. U.S.A. 98:575-580(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Orphan nuclear receptor small heterodimer partner, a novel corepressor for a basic helix-loop-helix transcription factor BETA2/neuroD."Mol. Endocrinol. 18:776-790(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP."Nat. Struct. Mol. Biol. 12:357-363(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Arginine methylation by PRMT5 at a naturally occurring mutation site is critical for liver metabolic regulation by small heterodimer partner."Mol. Cell. Biol. 31:1540-1550(2011) [PubMed] [Europe PMC] [Abstract]