Exportin 1 (XPO1)

[Edit]

Exp1; CRM1 Homolog,Yeast; Chromosome region maintenance 1 protein homolog

Exportin 1 (XPO1)

Exportin-1  mediates leucine-rich nuclear export signal (NES)-dependent protein transport. Exportin 1 specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2.

This protein also regulates NFAT and AP-1.The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. Several viruses, among them HIV-1, HTLV-1 and influenza A use it to export their unspliced or incompletely spliced RNAs out of the nucleus.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC258Hu01 Recombinant Exportin 1 (XPO1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC258Hu01 Polyclonal Antibody to Exportin 1 (XPO1) WB,IHC; FCM
MAC258Hu21 Monoclonal Antibody to Exportin 1 (XPO1) WB; IHC; ICC; IP.
Assay Kits SEC258Hu ELISA Kit for Exportin 1 (XPO1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Exportin 1 (XPO1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Exportin 1 (XPO1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Exportin 1 (XPO1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Exportin 1 (XPO1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Exportin 1 (XPO1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Exportin 1 (XPO1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Exportin 1 (XPO1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Exportin 1 (XPO1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Exportin 1 (XPO1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Exportin 1 (XPO1) ELISA Kit Customized Service Offer
  1. "The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and the novel nuclear pore component Nup88."EMBO J. 16:807-816(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning and cell cycle-dependent expression of mammalian CRM1, a protein involved in nuclear export of proteins."J. Biol. Chem. 272:29742-29751(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]