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Pirin (PIR)

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Iron Binding Nuclear Protein; Probable quercetin 2,3-dioxygenase PIR; Probable quercetinase

Pirin (PIR)
CCC C250
HGNC 30048
MGI 1916906
PubMed 23716661
RGD 1359212
UniProt O00625
Wiki Pirin

Pirin is an Fe(II)-containing nuclear protein expressed in all tissues of the body and concentrated within dot-like subnuclear structures. Interactions with nuclear factor I/CCAAT box transcription factor as well as B cell lymphoma 3-encoded oncoprotein suggest the encoded protein may act as a transcriptional cofactor and be involved in the regulation of DNA transcription and replication. Alternatively spliced transcript variants have been described.

Immunofluorescence studies indicated that pirin is localized in dot-like structures in the nucleus of mammalian cells. Antibodies against pirin recognized a single band in extracts of cells from several mammals, suggesting that pirin is conserved among mammals.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC250Hu01 Recombinant Pirin (PIR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC250Hu01 Polyclonal Antibody to Pirin (PIR) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Pirin (PIR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pirin (PIR) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pirin (PIR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pirin (PIR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pirin (PIR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pirin (PIR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pirin (PIR) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pirin (PIR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pirin (PIR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pirin (PIR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pirin (PIR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pirin (PIR) ELISA Kit Customized Service Offer
  1. "Identification of pirin, a novel highly conserved nuclear protein."J. Biol. Chem. 272:8482-8489(1997) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators."Oncogene 18:3316-3323(1999) [PubMed] [Europe PMC] [Abstract]
  4. "Structural and biochemical analysis reveal pirins to possess quercetinase activity."J. Biol. Chem. 280:28675-28682(2005) [PubMed] [Europe PMC] [Abstract]
  5. "Upregulation of pirin expression by chronic cigarette smoking is associated with bronchial epithelial cell apoptosis."Respir. Res. 8:10-10(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Pirin delocalization in melanoma progression identified by high content immuno-detection based approaches."BMC Cell Biol. 11:5-5(2010) [PubMed] [Europe PMC] [Abstract]
  7. "Sex-specific effect of Pirin gene on bone mineral density in a cohort of 4000 Chinese."Bone 46:543-550(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Pirin downregulation is a feature of AML and leads to impairment of terminal myeloid differentiation."Leukemia 24:429-437(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  11. "Crystal structure of human pirin: an iron-binding nuclear protein and transcription cofactor."J. Biol. Chem. 279:1491-1498(2004) [PubMed] [Europe PMC] [Abstract]
  12. "A small-molecule inhibitor shows that pirin regulates migration of melanoma cells."Nat. Chem. Biol. 6:667-673(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Pirin is an iron-dependent redox regulator of NF-kappaB."Proc. Natl. Acad. Sci. U.S.A. 110:9722-9727(2013) [PubMed] [Europe PMC] [Abstract]