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Nuclear Receptor Coactivator 6 (NCOA6)

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HOXA7; ANTP; PRIP; TRBP; AIB3; ASC2; NRC; RAP250; Amplified in breast cancer protein 3; Activating Signal Cointegrator-2; Peroxisome Proliferator-Activated Receptor Interacting

Nuclear Receptor Coactivator 6 (NCOA6)
CCC C240
HGNC 15936
MGI 1929915
PubMed 21292004
RGD 620111
UniProt Q14686
Wiki NCOA6

Nuclear receptor coactivator 6 is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D3, thyroid hormone, and steroid receptors. The encoded protein may also act as a general coactivator since it has been shown to interact with some basal transcription factors, histone acetyltransferases, and methyltransferases.Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nuclear Receptor Coactivator 6 (NCOA6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nuclear Receptor Coactivator 6 (NCOA6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nuclear Receptor Coactivator 6 (NCOA6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nuclear Receptor Coactivator 6 (NCOA6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nuclear Receptor Coactivator 6 (NCOA6) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC240Mu01 Recombinant Nuclear Receptor Coactivator 6 (NCOA6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Nuclear Receptor Coactivator 6 (NCOA6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nuclear Receptor Coactivator 6 (NCOA6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nuclear Receptor Coactivator 6 (NCOA6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nuclear Receptor Coactivator 6 (NCOA6) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nuclear Receptor Coactivator 6 (NCOA6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nuclear Receptor Coactivator 6 (NCOA6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nuclear Receptor Coactivator 6 (NCOA6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nuclear Receptor Coactivator 6 (NCOA6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nuclear Receptor Coactivator 6 (NCOA6) ELISA Kit Customized Service Offer
  1. "A nuclear factor ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo."J. Biol. Chem. 274:34283-34293(1999) [PubMed] [Europe PMC] [Abstract]
  2. "A new family of nuclear receptor coregulators that integrates nuclear receptor signaling through CBP."Mol. Cell. Biol. 20:5048-5063(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning and characterization of RAP250, a nuclear receptor coactivator."J. Biol. Chem. 275:5308-5317(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator."Proc. Natl. Acad. Sci. U.S.A. 97:6212-6217(2000) [PubMed] [Europe PMC] [Abstract]
  5. "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1."DNA Res. 3:17-24(1996) [PubMed] [Europe PMC] [Abstract]
  6. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  7. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Cloning and characterization of PIMT, a protein with a methyltransferase domain, which interacts with and enhances nuclear receptor coactivator PRIP function."Proc. Natl. Acad. Sci. U.S.A. 98:10380-10385(2001) [PubMed] [Europe PMC] [Abstract]
  10. "Identification and characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM)."J. Biol. Chem. 276:33375-33383(2001) [PubMed] [Europe PMC] [Abstract]
  11. "Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha."J. Biol. Chem. 277:28624-28630(2002) [PubMed] [Europe PMC] [Abstract]
  12. "NRC-interacting factor 1 is a novel cotransducer that interacts with and regulates the activity of the nuclear hormone receptor coactivator NRC."Mol. Cell. Biol. 22:6883-6894(2002) [PubMed] [Europe PMC] [Abstract]
  13. "Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins."Mol. Cell. Biol. 23:140-149(2003) [PubMed] [Europe PMC] [Abstract]
  14. "Ser-884 adjacent to the LXXLL motif of coactivator TRBP defines selectivity for ERs and TRs."Mol. Endocrinol. 16:128-140(2002) [PubMed] [Europe PMC] [Abstract]
  15. "Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases."Proc. Natl. Acad. Sci. U.S.A. 103:15392-15397(2006) [PubMed] [Europe PMC] [Abstract]
  16. "PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex."J. Biol. Chem. 282:20395-20406(2007) [PubMed] [Europe PMC] [Abstract]
  17. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  18. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]