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Lymphoid Enhancer Binding Factor 1 (LEF1)

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TCF1ALPHA; T cell-specific transcription factor 1-alpha

Lymphoid Enhancer Binding Factor 1 (LEF1)
CCC C215
HGNC 6551
MGI 96770
PubMed 16142310
RGD 620241
UniProt Q9UJU2
Wiki LEF1
Lymphoid enhancer-binding factor-1 (LEF1) is a 48-kD nuclear protein that is expressed in pre-B and T cells. It is a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1.
The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Lymphoid Enhancer Binding Factor 1 (LEF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Lymphoid Enhancer Binding Factor 1 (LEF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Lymphoid Enhancer Binding Factor 1 (LEF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Lymphoid Enhancer Binding Factor 1 (LEF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lymphoid Enhancer Binding Factor 1 (LEF1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Lymphoid Enhancer Binding Factor 1 (LEF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Lymphoid Enhancer Binding Factor 1 (LEF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Lymphoid Enhancer Binding Factor 1 (LEF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Lymphoid Enhancer Binding Factor 1 (LEF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lymphoid Enhancer Binding Factor 1 (LEF1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Lymphoid Enhancer Binding Factor 1 (LEF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Lymphoid Enhancer Binding Factor 1 (LEF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Lymphoid Enhancer Binding Factor 1 (LEF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Lymphoid Enhancer Binding Factor 1 (LEF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lymphoid Enhancer Binding Factor 1 (LEF1) ELISA Kit Customized Service Offer
  1. "A thymus-specific member of the HMG protein family regulates the human T cell receptor C alpha enhancer."Genes Dev. 5:656-669(1991) [PubMed] [Europe PMC] [Abstract]
  2. "The human LEF-1 gene contains a promoter preferentially active in lymphocytes and encodes multiple isoforms derived from alternative splicing."Nucleic Acids Res. 28:1994-2003(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Lef-1 isoforms regulate different target genes and reduce cellular adhesion."Int. J. Cancer 126:1109-1120(2010) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCRalpha enhancer function."Genes Dev. 11:640-653(1997) [PubMed] [Europe PMC] [Abstract]
  8. "Two members of the Tcf family implicated in Wnt/b-catenin signaling during embryogenesis in the mouse."Mol. Cell. Biol. 18:1248-1256(1998) [PubMed] [Europe PMC] [Abstract]
  9. "Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors."Proc. Natl. Acad. Sci. U.S.A. 95:11590-11595(1998) [PubMed] [Europe PMC] [Abstract]
  10. "Beta-catenin-sensitive isoforms of lymphoid enhancer factor-1 are selectively expressed in colon cancer."Nat. Genet. 28:53-57(2001) [PubMed] [Europe PMC] [Abstract]
  11. "All Tcf HMG box transcription factors interact with Groucho-related co-repressors."Nucleic Acids Res. 29:1410-1419(2001) [PubMed] [Europe PMC] [Abstract]
  12. "I-mfa domain proteins interact with Axin and affect its regulation of the Wnt and c-Jun N-terminal kinase signaling pathways."Mol. Cell. Biol. 22:6393-6405(2002) [PubMed] [Europe PMC] [Abstract]
  13. "Regulation of lymphoid enhancer factor 1/T-cell factor by mitogen-activated protein kinase-related Nemo-like kinase-dependent phosphorylation in Wnt/beta-catenin signaling."Mol. Cell. Biol. 23:1379-1389(2003) [PubMed] [Europe PMC] [Abstract]
  14. "An unappreciated role for RNA surveillance."Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  16. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]