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A Kinase Anchor Protein 11 (AKAP11)

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AKAP220; PRKA11; Protein Kinase A Anchoring Protein 11; A Kinase(PRKA)Anchor Protein 11; A-kinase anchor protein 220 kDa; Protein kinase A-anchoring protein 11

A Kinase Anchor Protein 11 (AKAP11)
CCC C197
HGNC 369
MGI 2684060
PubMed 21890631
RGD 2079
UniProt Q9UKA4
Wiki AKAP11
A-kinase anchor protein 11 is expressed at high levels throughout spermatogenesis and in mature sperm. It binds the RI and RII subunits of PKA in testis. It may serve a function in cell cycle control of both somatic cells and germ cells in addition to its putative role in spermatogenesis and sperm function. The AKAP11 protein has 1,129 amino acids and contains a PKA-binding region and a peroxisome targeting motif. Immunohistochemical analysis of rat testis cells showed that AKAP220 and a proportion of RII PKA are colocalized in microbodies that appear to be a subset of peroxisomes. By RT-PCR analysis, Ishikawa et al. (1998) detected expression of human AKAP11 in heart, brain, lung, liver, kidney, testis, and ovary, with weaker expression in skeletal muscle, pancreas, and spleen.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC197Hu01 Recombinant A Kinase Anchor Protein 11 (AKAP11) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC197Hu01 Polyclonal Antibody to A Kinase Anchor Protein 11 (AKAP11) WB; IHC; ICC/IF
Assay Kits n/a CLIA Kit for A Kinase Anchor Protein 11 (AKAP11) CLIA Kit Customized Service Offer
n/a ELISA Kit for A Kinase Anchor Protein 11 (AKAP11) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant A Kinase Anchor Protein 11 (AKAP11) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to A Kinase Anchor Protein 11 (AKAP11) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to A Kinase Anchor Protein 11 (AKAP11) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for A Kinase Anchor Protein 11 (AKAP11) CLIA Kit Customized Service Offer
n/a ELISA Kit for A Kinase Anchor Protein 11 (AKAP11) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant A Kinase Anchor Protein 11 (AKAP11) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to A Kinase Anchor Protein 11 (AKAP11) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to A Kinase Anchor Protein 11 (AKAP11) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for A Kinase Anchor Protein 11 (AKAP11) CLIA Kit Customized Service Offer
n/a ELISA Kit for A Kinase Anchor Protein 11 (AKAP11) ELISA Kit Customized Service Offer
  1. "Localization of a novel human A-kinase-anchoring protein, hAKAP220, during spermatogenesis."Dev. Biol. 223:194-204(2000) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and analysis of human chromosome 13." Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
  4. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]