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Beta Adrenergic Receptor Kinase (BARK)

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ADRbK1; B-ARK1; bARK1; Beta-ARK1; GRK2; G-protein coupled receptor kinase 2; Adrenergic Receptor Beta Kinase 1

Beta Adrenergic Receptor Kinase (BARK)
CCC C189
HGNC 289
MGI 87940
PubMed 21127457
RGD 2062
UniProt P25098
Wiki ADRBK1

Beta-adrenergic receptor kinase (BARK) phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. BARK is a ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G protein-coupled receptors.

By study of rodent/human hybrid cells retaining various human chromosomes and parts of chromosomes, Benovic et al. (1991) demonstrated that the ADRBK1 gene segregates with the long arm of chromosome 11, centromeric to 11q13, i.e., 11cen-q13. Benovic et al. (1991) mapped the homologous gene to mouse chromosome 19.

 

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC189Hu01 Recombinant Beta Adrenergic Receptor Kinase (BARK) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC189Hu01 Polyclonal Antibody to Beta Adrenergic Receptor Kinase (BARK) WB; IHC; ICC; IP.
MAC189Hu21 Monoclonal Antibody to Beta Adrenergic Receptor Kinase (BARK) WB; IHC; ICC; IP.
Assay Kits SEC189Hu ELISA Kit for Beta Adrenergic Receptor Kinase (BARK) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Beta Adrenergic Receptor Kinase (BARK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Beta Adrenergic Receptor Kinase (BARK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Beta Adrenergic Receptor Kinase (BARK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Beta Adrenergic Receptor Kinase (BARK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Beta Adrenergic Receptor Kinase (BARK) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Beta Adrenergic Receptor Kinase (BARK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Beta Adrenergic Receptor Kinase (BARK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Beta Adrenergic Receptor Kinase (BARK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Beta Adrenergic Receptor Kinase (BARK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Beta Adrenergic Receptor Kinase (BARK) ELISA Kit Customized Service Offer
  1. "cDNA cloning and chromosomal localization of the human beta-adrenergic receptor kinase."FEBS Lett. 283:122-126(1991) [PubMed] [Europe PMC] [Abstract]
  2. "High expression of beta-adrenergic receptor kinase in human peripheral blood leukocytes. Isoproterenol and platelet activating factor can induce kinase translocation."J. Biol. Chem. 267:6886-6892(1992) [PubMed] [Europe PMC] [Abstract]
  3. "Structure of the human gene encoding the beta-adrenergic receptor kinase."J. Biol. Chem. 269:14924-14930(1994) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Monocyte chemoattractant protein-1-induced CCR2B receptor desensitization mediated by the G protein-coupled receptor kinase 2."Proc. Natl. Acad. Sci. U.S.A. 95:2985-2990(1998) [PubMed] [Europe PMC] [Abstract]
  6. "Differential effects of CC chemokines on CC chemokine receptor 5 (CCR5) phosphorylation and identification of phosphorylation sites on the CCR5 carboxyl terminus."J. Biol. Chem. 274:8875-8885(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Dual regulation of lysophosphatidic acid (LPA1) receptor signalling by Ral and GRK."Cell. Signal. 21:1207-1217(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "The solution structure and dynamics of the pleckstrin homology domain of G protein-coupled receptor kinase 2 (beta-adrenergic receptor kinase 1). A binding partner of Gbetagamma subunits."J. Biol. Chem. 273:2835-2843(1998) [PubMed] [Europe PMC] [Abstract]
  11. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]