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Erb-b2 Receptor Tyrosine Kinase 4 (ErbB4)

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HER4; P180erbB4; V-Erb A Erythroblastic Leukemia Viral Oncogene Homolog 4; Proto-oncogene-like protein c-ErbB-4; Tyrosine kinase-type cell surface receptor HER4

Erb-b2 Receptor Tyrosine Kinase 4 (ErbB4)
CCC C188
HGNC 3432
MGI 104771
PubMed 22076439
RGD 620486
UniProt Q15303
Wiki ERBB4

ErbB-4 is a member of the epidermal growth factor receptor subfamily. ERBB4 is a single-pass type I transmembrane protein with multiple furin-like cysteine rich domains, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins-2 and -3, heparin-binding EGF-like growth factor and betacellulin. Ligand binding induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC188Hu01 Recombinant Erb-b2 Receptor Tyrosine Kinase 4 (ErbB4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC188Hu01 Polyclonal Antibody to Erb-b2 Receptor Tyrosine Kinase 4 (ErbB4) WB; IHC; ICC; IP.
MAC188Hu21 Monoclonal Antibody to Erb-b2 Receptor Tyrosine Kinase 4 (ErbB4) WB; IHC; ICC; IP.
Assay Kits SEC188Hu ELISA Kit for Erb-b2 Receptor Tyrosine Kinase 4 (ErbB4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Erb-b2 Receptor Tyrosine Kinase 4 (ErbB4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Erb-b2 Receptor Tyrosine Kinase 4 (ErbB4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Erb-b2 Receptor Tyrosine Kinase 4 (ErbB4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Erb-b2 Receptor Tyrosine Kinase 4 (ErbB4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Erb-b2 Receptor Tyrosine Kinase 4 (ErbB4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Erb-b2 Receptor Tyrosine Kinase 4 (ErbB4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Erb-b2 Receptor Tyrosine Kinase 4 (ErbB4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Erb-b2 Receptor Tyrosine Kinase 4 (ErbB4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Erb-b2 Receptor Tyrosine Kinase 4 (ErbB4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Erb-b2 Receptor Tyrosine Kinase 4 (ErbB4) ELISA Kit Customized Service Offer
  1. "Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family."Proc. Natl. Acad. Sci. U.S.A. 90:1746-1750(1993) [PubMed] [Europe PMC] [Abstract]
  2. "A novel juxtamembrane domain isoform of HER4/ErbB4. Isoform-specific tissue distribution and differential processing in response to phorbol ester."J. Biol. Chem. 272:26761-26768(1997) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Characterization of a breast cancer cell differentiation factor that specifically activates the HER4/p180erbB4 receptor."J. Biol. Chem. 268:18407-18410(1993) [PubMed] [Europe PMC] [Abstract]
  5. "Heregulin induces tyrosine phosphorylation of HER4/p180erbB4."Nature 366:473-475(1993) [PubMed] [Europe PMC] [Abstract]
  6. "HER4-mediated biological and biochemical properties in NIH 3T3 cells. Evidence for HER1-HER4 heterodimers."J. Biol. Chem. 271:4813-4818(1996) [PubMed] [Europe PMC] [Abstract]
  7. "Betacellulin activates the epidermal growth factor receptor and erbB-4, and induces cellular response patterns distinct from those stimulated by epidermal growth factor or neuregulin-beta."Oncogene 12:345-353(1996) [PubMed] [Europe PMC] [Abstract]
  8. "Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation."EMBO J. 16:1268-1278(1997) [PubMed] [Europe PMC] [Abstract]
  9. "Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases."Nature 387:512-516(1997) [PubMed] [Europe PMC] [Abstract]
  10. "Epiregulin binds to epidermal growth factor receptor and ErbB-4 and induces tyrosine phosphorylation of epidermal growth factor receptor, ErbB-2, ErbB-3 and ErbB-4."Oncogene 15:2841-2848(1997) [PubMed] [Europe PMC] [Abstract]
  11. "Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4."Proc. Natl. Acad. Sci. U.S.A. 94:9562-9567(1997) [PubMed] [Europe PMC] [Abstract]
  12. "Analysis of Grb7 recruitment by heregulin-activated erbB receptors reveals a novel target selectivity for erbB3."J. Biol. Chem. 273:7717-7724(1998) [PubMed] [Europe PMC] [Abstract]
  13. "ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases."J. Biol. Chem. 274:17209-17218(1999) [PubMed] [Europe PMC] [Abstract]
  14. "Characterization of a naturally occurring ErbB4 isoform that does not bind or activate phosphatidyl inositol 3-kinase."Oncogene 18:2607-2615(1999) [PubMed] [Europe PMC] [Abstract]
  15. "Neuregulin-4: a novel growth factor that acts through the ErbB-4 receptor tyrosine kinase."Oncogene 18:2681-2689(1999) [PubMed] [Europe PMC] [Abstract]
  16. "A natural ErbB4 isoform that does not activate phosphoinositide 3-kinase mediates proliferation but not survival or chemotaxis."J. Biol. Chem. 275:8641-8649(2000) [PubMed] [Europe PMC] [Abstract]
  17. "Tumor necrosis factor-alpha-converting enzyme is required for cleavage of erbB4/HER4."J. Biol. Chem. 275:10379-10387(2000) [PubMed] [Europe PMC] [Abstract]
  18. "Ligand discrimination in signaling through an ErbB4 receptor homodimer."J. Biol. Chem. 275:19803-19807(2000) [PubMed] [Europe PMC] [Abstract]
  19. "The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses."Proc. Natl. Acad. Sci. U.S.A. 97:3596-3601(2000) [PubMed] [Europe PMC] [Abstract]
  20. "BIBX1382BS, but not AG1478 or PD153035, inhibits the ErbB kinases at different concentrations in intact cells."Biochem. Biophys. Res. Commun. 281:25-31(2001) [PubMed] [Europe PMC] [Abstract]
  21. "Her4 mediates ligand-dependent antiproliferative and differentiation responses in human breast cancer cells."Mol. Cell. Biol. 21:4265-4275(2001) [PubMed] [Europe PMC] [Abstract]
  22. "WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus."J. Biol. Chem. 278:33334-33341(2003) [PubMed] [Europe PMC] [Abstract]
  23. "Heregulin targets gamma-catenin to the nucleolus by a mechanism dependent on the DF3/MUC1 oncoprotein."Mol. Cancer Res. 1:765-775(2003) [PubMed] [Europe PMC] [Abstract]
  24. "The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone."J. Cell Biol. 167:469-478(2004) [PubMed] [Europe PMC] [Abstract]
  25. "WW domain-containing proteins, WWOX and YAP, compete for interaction with ErbB-4 and modulate its transcriptional function."Cancer Res. 65:6764-6772(2005) [PubMed] [Europe PMC] [Abstract]
  26. "Presenilin-dependent gamma-secretase processing regulates multiple ERBB4/HER4 activities."J. Biol. Chem. 280:19777-19783(2005) [PubMed] [Europe PMC] [Abstract]
  27. "The ERBB4/HER4 intracellular domain 4ICD is a BH3-only protein promoting apoptosis of breast cancer cells."Cancer Res. 66:6412-6420(2006) [PubMed] [Europe PMC] [Abstract]
  28. "ErbB-4 s80 intracellular domain abrogates ETO2-dependent transcriptional repression."J. Biol. Chem. 281:25373-25380(2006) [PubMed] [Europe PMC] [Abstract]
  29. "Proteolytic cleavage and phosphorylation of a tumor-associated ErbB4 isoform promote ligand-independent survival and cancer cell growth."Mol. Biol. Cell 17:67-79(2006) [PubMed] [Europe PMC] [Abstract]
  30. "The intracellular domain of ErbB4 induces differentiation of mammary epithelial cells."Mol. Biol. Cell 17:4118-4129(2006) [PubMed] [Europe PMC] [Abstract]
  31. "Phosphorylation of ErbB4 on tyrosine 1056 is critical for ErbB4 coupling to inhibition of colony formation by human mammary cell lines."Oncol. Res. 16:179-193(2006) [PubMed] [Europe PMC] [Abstract]
  32. "HER4 D-box sequences regulate mitotic progression and degradation of the nuclear HER4 cleavage product s80HER4."Cancer Res. 67:6582-6590(2007) [PubMed] [Europe PMC] [Abstract]
  33. "Neuregulin-1 only induces trans-phosphorylation between ErbB receptor heterodimer partners."Cell. Signal. 19:466-471(2007) [PubMed] [Europe PMC] [Abstract]
  34. "Differential nuclear localization and kinase activity of alternative ErbB4 intracellular domains."Oncogene 26:6905-6914(2007) [PubMed] [Europe PMC] [Abstract]
  35. "System-wide investigation of ErbB4 reveals 19 sites of Tyr phosphorylation that are unusually selective in their recruitment properties."Chem. Biol. 15:808-817(2008) [PubMed] [Europe PMC] [Abstract]
  36. "Nedd4 mediates ErbB4 JM-a/CYT-1 ICD ubiquitination and degradation in MDCK II cells."FASEB J. 23:1935-1945(2009) [PubMed] [Europe PMC] [Abstract]
  37. "Somatic mutations of ErbB4: selective loss-of-function phenotype affecting signal transduction pathways in cancer."J. Biol. Chem. 284:5582-5591(2009) [PubMed] [Europe PMC] [Abstract]
  38. "WW domain containing E3 ubiquitin protein ligase 1 targets the full-length ErbB4 for ubiquitin-mediated degradation in breast cancer."Oncogene 28:2948-2958(2009) [PubMed] [Europe PMC] [Abstract]
  39. "Interactions of ErbB4 and Kap1 connect the growth factor and DNA damage response pathways."Mol. Cancer Res. 8:1388-1398(2010) [PubMed] [Europe PMC] [Abstract]
  40. "Small tyrosine kinase inhibitors interrupt EGFR signaling by interacting with erbB3 and erbB4 in glioblastoma cell lines."Exp. Cell Res. 317:1476-1489(2011) [PubMed] [Europe PMC] [Abstract]
  41. "ErbB4 signaling during breast and neural development: novel genetic models reveal unique ErbB4 activities."Cell Cycle 2:555-559(2003) [PubMed] [Europe PMC] [Abstract]
  42. "The diverse signaling network of EGFR, HER2, HER3 and HER4 tyrosine kinase receptors and the consequences for therapeutic approaches."Histol. Histopathol. 20:1005-1015(2005) [PubMed] [Europe PMC] [Abstract]
  43. "ErbB4/HER4: role in mammary gland development, differentiation and growth inhibition."J. Mammary Gland Biol. Neoplasia 13:235-246(2008) [PubMed] [Europe PMC] [Abstract]
  44. "HER4 intracellular domain (4ICD) activity in the developing mammary gland and breast cancer."J. Mammary Gland Biol. Neoplasia 13:247-258(2008) [PubMed] [Europe PMC] [Abstract]
  45. "Role of ErbB4 in breast cancer."J. Mammary Gland Biol. Neoplasia 13:259-268(2008) [PubMed] [Europe PMC] [Abstract]
  46. "Neuregulin-1/ErbB signaling and chronic heart failure."Adv. Pharmacol. 59:31-51(2010) [PubMed] [Europe PMC] [Abstract]
  47. "Function of ERBB4 is determined by alternative splicing."Cell Cycle 10:2647-2657(2011) [PubMed] [Europe PMC] [Abstract]
  48. "The extracellular region of ErbB4 adopts a tethered conformation in the absence of ligand."Proc. Natl. Acad. Sci. U.S.A. 102:15024-15029(2005) [PubMed] [Europe PMC] [Abstract]
  49. "6-Ethynylthieno[3,2-d]- and 6-ethynylthieno[2,3-d]pyrimidin-4-anilines as tunable covalent modifiers of ErbB kinases." Proc. Natl. Acad. Sci. U.S.A. 105:2773-2778(2008) [PubMed] [Europe PMC] [Abstract]
  50. "Mechanism of activation and inhibition of the HER4/ErbB4 kinase."Structure 16:460-467(2008) [PubMed] [Europe PMC] [Abstract]
  51. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
  52. "ERBB4 mutations that disrupt the neuregulin-ErbB4 pathway cause amyotrophic lateral sclerosis type 19." Am. J. Hum. Genet. 93:900-905(2013) [PubMed] [Europe PMC] [Abstract]