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Neurotrophic Tyrosine Kinase Receptor Type 1 (NTRK1)

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MTC; TRK1; TRK-A; P140-TrkA; High Affinity Nerve Growth Factor Receptor; TRK1 Transforming Tyrosine Kinase Protein; Tropomyosin-related kinase A; Tyrosine kinase receptor

Neurotrophic Tyrosine Kinase Receptor Type 1 (NTRK1)
CCC C182
HGNC 8031
MGI 97383
PubMed 10982191
RGD 620144
UniProt P04629
Wiki NTRK1
High affinity nerve growth factor receptor is a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself (autophosphorylation) and members of the MAPK pathway.
The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain with anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.TrkA is part of a sub-family of protein kinases which includes TrkB and TrkC.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC182Hu01 Recombinant Neurotrophic Tyrosine Kinase Receptor Type 1 (NTRK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAC182Hu21 Monoclonal Antibody to Neurotrophic Tyrosine Kinase Receptor Type 1 (NTRK1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Neurotrophic Tyrosine Kinase Receptor Type 1 (NTRK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Neurotrophic Tyrosine Kinase Receptor Type 1 (NTRK1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Neurotrophic Tyrosine Kinase Receptor Type 1 (NTRK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Neurotrophic Tyrosine Kinase Receptor Type 1 (NTRK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Neurotrophic Tyrosine Kinase Receptor Type 1 (NTRK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Neurotrophic Tyrosine Kinase Receptor Type 1 (NTRK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Neurotrophic Tyrosine Kinase Receptor Type 1 (NTRK1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Neurotrophic Tyrosine Kinase Receptor Type 1 (NTRK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Neurotrophic Tyrosine Kinase Receptor Type 1 (NTRK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Neurotrophic Tyrosine Kinase Receptor Type 1 (NTRK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Neurotrophic Tyrosine Kinase Receptor Type 1 (NTRK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Neurotrophic Tyrosine Kinase Receptor Type 1 (NTRK1) ELISA Kit Customized Service Offer
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  7. "Methylation adjacent to negatively regulating AP-1 site reactivates TrkA gene expression during cancer progression."Oncogene 24:5108-5118(2005) [PubMed] [Europe PMC] [Abstract]
  8. "A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences."Nature 319:743-748(1986) [PubMed] [Europe PMC] [Abstract]
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  10. "The DNA rearrangement that generates the TRK-T3 oncogene involves a novel gene on chromosome 3 whose product has a potential coiled-coil domain."Mol. Cell. Biol. 15:6118-6127(1995) [PubMed] [Europe PMC] [Abstract]
  11. "TRK-T1 is a novel oncogene formed by the fusion of TPR and TRK genes in human papillary thyroid carcinomas."Oncogene 7:237-242(1992) [PubMed] [Europe PMC] [Abstract]
  12. "High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor."Nature 350:678-683(1991) [PubMed] [Europe PMC] [Abstract]
  13. "The trk proto-oncogene encodes a receptor for nerve growth factor."Cell 65:189-197(1991) [PubMed] [Europe PMC] [Abstract]
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  15. "A Trk nerve growth factor (NGF) receptor point mutation affecting interaction with phospholipase C-gamma 1 abolishes NGF-promoted peripherin induction but not neurite outgrowth."J. Biol. Chem. 269:8901-8910(1994) [PubMed] [Europe PMC] [Abstract]
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  17. "The atypical protein kinase C-interacting protein p62 is a scaffold for NF-kappaB activation by nerve growth factor."J. Biol. Chem. 276:7709-7712(2001) [PubMed] [Europe PMC] [Abstract]
  18. "TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma."Cancer Cell 6:347-360(2004) [PubMed] [Europe PMC] [Abstract]
  19. "Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling."Nat. Neurosci. 14:54-61(2011) [PubMed] [Europe PMC] [Abstract]
  20. "Structure and ligand recognition of the phosphotyrosine binding domain of Shc."Nature 378:584-592(1995) [PubMed] [Europe PMC] [Abstract]
  21. "Crystal structures of the neurotrophin-binding domain of TrkA, TrkB and TrkC."J. Mol. Biol. 290:149-159(1999) [PubMed] [Europe PMC] [Abstract]
  22. "Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor."Nature 401:184-188(1999) [PubMed] [Europe PMC] [Abstract]
  23. "Structural and mechanistic insights into nerve growth factor interactions with the TrkA and p75 receptors."Neuron 53:25-38(2007) [PubMed] [Europe PMC] [Abstract]
  24. "Mutations in the TRKA/NGF receptor gene in patients with congenital insensitivity to pain with anhidrosis."Nat. Genet. 13:485-488(1996) [PubMed] [Europe PMC] [Abstract]
  25. "A novel NTRK1 mutation associated with congenital insensitivity to pain with anhidrosis."Am. J. Hum. Genet. 64:1207-1210(1999) [PubMed] [Europe PMC] [Abstract]
  26. "Congenital insensitivity to pain with anhidrosis: novel mutations in the TRKA (NTRK1) gene encoding a high-affinity receptor for nerve growth factor."Am. J. Hum. Genet. 64:1570-1579(1999) [PubMed] [Europe PMC] [Abstract]
  27. "Mutation analysis reveals novel sequence variants in NTRK1 in sporadic human medullary thyroid carcinoma."J. Clin. Endocrinol. Metab. 84:2784-2787(1999) [PubMed] [Europe PMC] [Abstract]
  28. "A novel point mutation affecting the tyrosine kinase domain of the TRKA gene in a family with congenital insensitivity to pain with anhidrosis."J. Invest. Dermatol. 112:810-814(1999) [PubMed] [Europe PMC] [Abstract]
  29. "Characterization of single-nucleotide polymorphisms in coding regions of human genes."Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract]
  30. ErratumNat. Genet. 23:373-373(1999)
  31. "Congenital insensitivity to pain with anhidrosis (CIPA) in Israeli-Bedouins: genetic heterogeneity, novel mutations in the TRKA/NGF receptor gene, clinical findings, and results of nerve conduction studies."Am. J. Med. Genet. 92:353-360(2000) [PubMed] [Europe PMC] [Abstract]
  32. "Mutation and polymorphism analysis of the TRKA (NTRK1) gene encoding a high-affinity receptor for nerve growth factor in congenital insensitivity to pain with anhidrosis (CIPA) families."Hum. Genet. 106:116-124(2000) [PubMed] [Europe PMC] [Abstract]
  33. "The Gly571Arg mutation, associated with the autonomic and sensory disorder congenital insensitivity to pain with anhidrosis, causes the inactivation of the NTRK1/nerve growth factor receptor."J. Cell. Physiol. 182:127-133(2000) [PubMed] [Europe PMC] [Abstract]
  34. "A novel TRK A (NTRK1) mutation associated with hereditary sensory and autonomic neuropathy type V."Ann. Neurol. 49:521-525(2001) [PubMed] [Europe PMC] [Abstract]
  35. "Congenital insensitivity to pain with anhidrosis (CIPA): effect of TRKA (NTRK1) missense mutations on autophosphorylation of the receptor tyrosine kinase for nerve growth factor."Hum. Mol. Genet. 10:179-188(2001) [PubMed] [Europe PMC] [Abstract]
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  37. "Frequency of mutations in the genes associated with hereditary sensory and autonomic neuropathy in a UK cohort." J. Neurol. 259:1673-1685(2012) [PubMed] [Europe PMC] [Abstract]