Neuregulin 2 (NRG2)
[Edit]Don-1; HRG2; NTAK; Neural And Thymus Derived Activator For ErbB Kinases; Divergent Of Neuregulin-1; Pro-neuregulin-2, membrane-bound isoform
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Neuregulin 2 (NRG2) is a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ErbB family of receptors, NRG2 induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1 (NRG1), another member of the neuregulin family of ligands. NRG1 and NRG2 mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells.
The gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease. Alternative transcripts encoding distinct isoforms have been described.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC172Hu01 | Recombinant Neuregulin 2 (NRG2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAC172Hu01 | Polyclonal Antibody to Neuregulin 2 (NRG2) | WB; IHC; ICC; IP. |
| MAC172Hu22 | Monoclonal Antibody to Neuregulin 2 (NRG2) | WB; IHC; ICC; IP. | |
| LAC172Hu71 | Biotin-Linked Polyclonal Antibody to Neuregulin 2 (NRG2) | WB; IHC; ICC. | |
| Assay Kits | SEC172Hu | ELISA Kit for Neuregulin 2 (NRG2) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Neuregulin 2 (NRG2) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Neuregulin 2 (NRG2) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Neuregulin 2 (NRG2) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Neuregulin 2 (NRG2) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Neuregulin 2 (NRG2) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC172Ra01 | Recombinant Neuregulin 2 (NRG2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAC172Ra01 | Polyclonal Antibody to Neuregulin 2 (NRG2) | WB; IHC; ICC; IP. |
| MAC172Ra21 | Monoclonal Antibody to Neuregulin 2 (NRG2) | WB; IHC; ICC; IP. | |
| Assay Kits | SEC172Ra | ELISA Kit for Neuregulin 2 (NRG2) | Enzyme-linked immunosorbent assay for Antigen Detection. |
- "A novel brain-derived member of the epidermal growth factor family that interacts with ErbB3 and ErbB4."J. Biochem. 122:675-680(1997) [PubMed] [Europe PMC] [Abstract]
- "Characterization of a neuregulin-related gene, Don-1, that is highly expressed in restricted regions of the cerebellum and hippocampus."Mol. Cell. Biol. 17:4007-4014(1997) [PubMed] [Europe PMC] [Abstract]
- "The human neuregulin 2 (NRG2) gene: cloning, mapping and evaluation as a candidate for the autosomal recessive form of Charcot-Marie-Tooth disease linked to 5q."Hum. Genet. 104:326-332(1999) [PubMed] [Europe PMC] [Abstract]
- "Ligand discrimination in signaling through an ErbB4 receptor homodimer."J. Biol. Chem. 275:19803-19807(2000) [PubMed] [Europe PMC] [Abstract]