≡

Major Histocompatibility Complex Class II DP Beta 1 (MHCDPb1)

[Edit]

HLA-DPB1; HLADPb1; HLA-DP1B; MHC-DPB1; HLA Class II Histocompatibility Antigen,DP(W2)Beta Chain

Major Histocompatibility Complex Class II DP Beta 1 (MHCDPb1)
CCC C162
HGNC 4940
PubMed 12615603
UniProt P04232
Wiki HLA-DPB1

HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Major Histocompatibility Complex Class II DP Beta 1 (MHCDPb1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Major Histocompatibility Complex Class II DP Beta 1 (MHCDPb1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Major Histocompatibility Complex Class II DP Beta 1 (MHCDPb1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Major Histocompatibility Complex Class II DP Beta 1 (MHCDPb1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Major Histocompatibility Complex Class II DP Beta 1 (MHCDPb1) ELISA Kit Customized Service Offer
  1. "Structure and polymorphism of the HLA class II SB light chain genes."EMBO J. 3:2985-2993(1984) [PubMed] [Europe PMC] [Abstract]
  2. "DO beta: a new beta chain gene in HLA-D with a distinct regulation of expression."EMBO J. 4:2839-2847(1985) [PubMed] [Europe PMC] [Abstract]
  3. "Complete nucleotide sequence of a functional HLA-DP beta gene and the region between the DP beta 1 and DP alpha 1 genes: comparison of the 5' ends of HLA class II genes."Nucleic Acids Res. 13:1607-1621(1985) [PubMed] [Europe PMC] [Abstract]
  4. "Class II genes of the human major histocompatibility complex. Evolution of the DP region as deduced from nucleotide sequences of the four genes."J. Biol. Chem. 262:8778-8786(1987) [PubMed] [Europe PMC] [Abstract]
  5. "The beta-chains of DP4 molecules from different haplotypes are encoded by the same gene."Genomics 2:8-13(1988) [PubMed] [Europe PMC] [Abstract]
  6. "A new HLA-DPB1 allele from a patient with systemic lupus erythematosus."Tissue Antigens 39:216-219(1992) [PubMed] [Europe PMC] [Abstract]
  7. "Extended HLA-DPB1 polymorphism: an RNA approach for HLA-DPB1 typing."Immunogenetics 57:790-794(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  9. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Sequence polymorphism of HLA-DP beta chains."Immunogenetics 29:346-349(1989) [PubMed] [Europe PMC] [Abstract]
  12. "HLA-DPB1 alleles in a population from north India and description of a new variant (DPB1*5601)."Tissue Antigens 45:264-269(1995) [PubMed] [Europe PMC] [Abstract]
  13. "Characterization of novel HLA-DPB1 alleles by oligotyping and nucleotide sequencing."Tissue Antigens 40:261-263(1992) [PubMed] [Europe PMC] [Abstract]
  14. "DPB1*TF, a novel HLA class II DPB1 allele (DPB1*6701) identified in a Turkish family."Tissue Antigens 48:231-232(1996) [PubMed] [Europe PMC] [Abstract]
  15. "Identification of two new DPB1 alleles, DPB1*7701 and *7801, by sequence-based typing."Tissue Antigens 52:190-192(1998) [PubMed] [Europe PMC] [Abstract]
  16. "Identification of a new DPB1 allele (DPB1*7901) by sequence-based typing."Tissue Antigens 52:193-195(1998) [PubMed] [Europe PMC] [Abstract]
  17. "DNA-sequence determination of exon 2 of a novel HLA-DPB1 allele, HLA-DPB1*0403."DNA Seq. 16:235-236(2005) [PubMed] [Europe PMC] [Abstract]
  18. "Genetic diversity within the HLA class II region: ten new DPB1 alleles and their population distribution."Tissue Antigens 40:153-157(1992) [PubMed] [Europe PMC] [Abstract]
  19. "Identification of the novel HLA-DPB1*5801 allele detected by sequenced based typing."Immunogenetics 41:173-173(1995) [PubMed] [Europe PMC] [Abstract]
  20. "Three new DPB1 alleles identified in a Bantu-speaking population from central Cameroon."Tissue Antigens 47:293-299(1996) [PubMed] [Europe PMC] [Abstract]
  21. "Molecular organization of the HLA-SB region of the human major histocompatibility complex and evidence for two SB beta-chain genes."Proc. Natl. Acad. Sci. U.S.A. 81:3934-3938(1984) [PubMed] [Europe PMC] [Abstract]
  22. "In a study for acne vulgaris, sequence-based HLA typing showed a novel DPB1 allele, DPB1*2402."Tissue Antigens 74:354-356(2009) [PubMed] [Europe PMC] [Abstract]
  23. "Analysis of HLA-DP allelic sequence polymorphism using the in vitro enzymatic DNA amplification of DP-alpha and DP-beta loci."J. Immunol. 141:4024-4030(1988) [PubMed] [Europe PMC] [Abstract]
  24. "Rapid HLA-DPB typing using enzymatically amplified DNA and nonradioactive sequence-specific oligonucleotide probes."Immunogenetics 32:231-241(1990) [PubMed] [Europe PMC] [Abstract]
  25. "Novel class II HLA-DRB4 and DPB1 alleles found in the Belgian population."Immunogenetics 38:380-380(1993) [PubMed] [Europe PMC] [Abstract]
  26. "Identification of a new HLA-DPB1 allele detected by PCR-RFLP and its nucleotide sequence determination by direct sequencing after PCR amplification."Tissue Antigens 41:259-262(1993) [PubMed] [Europe PMC] [Abstract]
  27. "A new HLA-DPB1 allele, DPB1*SUT (DPB1*4701)."Tissue Antigens 43:50-53(1994) [PubMed] [Europe PMC] [Abstract]
  28. "Direct sequencing of a novel DPB1 allele (DPB1*5101) of the heterozygote from the membrane of reverse dot blot analysis."Tissue Antigens 44:204-207(1994) [PubMed] [Europe PMC] [Abstract]
  29. "DPB1*BR: an Mhc class II DPB1 allele (DPB1*6601) of negroid origin."Immunogenetics 44:405-406(1996) [PubMed] [Europe PMC] [Abstract]
  30. "Identification of a new HLA-DPB1*6501 allele in a Caucasian individual."Immunogenetics 44:483-484(1996) [PubMed] [Europe PMC] [Abstract]
  31. "Two new HLA DPB1 alleles identified by sequence-based typing: DPB1*8201 and DPB1*8301."Tissue Antigens 56:560-562(2000) [PubMed] [Europe PMC] [Abstract]
  32. "DPB1*8601, a previously unrecognized DPB1 variant in the Caucasoid population."Tissue Antigens 57:536-539(2001) [PubMed] [Europe PMC] [Abstract]
  33. "Three new DP alleles identified in a study of 800 unrelated bone marrow donor-recipient pairs."Tissue Antigens 58:272-275(2001) [PubMed] [Europe PMC] [Abstract]
  34. "Identification of a new HLA-DPB1 allele,HLA-DPB1*9001."Tissue Antigens 59:344-346(2002) [PubMed] [Europe PMC] [Abstract]
  35. "Identification of a novel DPB1 allele, DPB1*9301, by sequence-based typing in a Lahu ethnic minority of China."Tissue Antigens 61:261-262(2003) [PubMed] [Europe PMC] [Abstract]
  36. "High resolution sequence-based DPB1 typing identified two novel DPB1 alleles, DPB1*9401 and DPB1*9501, from a Kenyan population."Tissue Antigens 62:182-184(2003) [PubMed] [Europe PMC] [Abstract]
  37. "Sequence-based typing identifies a novel HLA-DPB1 allele, DPB1*9601."Tissue Antigens 62:185-187(2003) [PubMed] [Europe PMC] [Abstract]
  38. "Identification of a novel HLA-DPB1 allele--DPB1*0102."Tissue Antigens 64:512-514(2004) [PubMed] [Europe PMC] [Abstract]
  39. "Identification of a novel HLA-DPB1 allele, DPB1*1702."Tissue Antigens 68:187-188(2006) [PubMed] [Europe PMC] [Abstract]
  40. "Seven new DPB1 alleles and their population distribution."Tissue Antigens 43:249-252(1994) [PubMed] [Europe PMC] [Abstract]
  41. "Six new DPB1 alleles identified in a study of 1,302 unrelated bone marrow donor-recipient pairs."Tissue Antigens 49:512-516(1997) [PubMed] [Europe PMC] [Abstract]
  42. "Four new DP alleles identified in a study of 500 unrelated bone marrow donor-recipient pairs."Tissue Antigens 53:201-206(1999) [PubMed] [Europe PMC] [Abstract]
  43. "Identification of a novel HLA-DPB1 allele, DPB1*9701, by sequence-based typing."Tissue Antigens 63:606-608(2004) [PubMed] [Europe PMC] [Abstract]
  44. "Novel HLA-DPB1 alleles detected in the Ethiopian population."Hum. Immunol. 42:181-183(1995) [PubMed] [Europe PMC] [Abstract]
  45. "DPB1*5901a: a novel HLA-DPB1 allele from a Caucasian family with insulin-dependent diabetes mellitus."Tissue Antigens 47:159-162(1996) [PubMed] [Europe PMC] [Abstract]
  46. "Identification of a new allele in a Sicilian individual: HLA-DPB1*0302."Tissue Antigens 66:64-66(2005) [PubMed] [Europe PMC] [Abstract]
  47. "DPB1*WA4 - an additional HLA class II allele identified in west Africa."Tissue Antigens 40:98-99(1992) [PubMed] [Europe PMC] [Abstract]
  48. "Family study on HLA-DPB1 polymorphism: linkage analysis with HLA-DR/DQ and two 'new' alleles."Hum. Immunol. 34:203-211(1992) [PubMed] [Europe PMC] [Abstract]
  49. "A novel HLA-DPB1 allele, DPB1*3601 (DPB1*KT)."Tissue Antigens 44:134-136(1994) [PubMed] [Europe PMC] [Abstract]
  50. "Three new DP alleles identified in sub-Saharan Africa: DPB1*7401, DPA1*02013, and DPA1*0302."Tissue Antigens 51:653-657(1998) [PubMed] [Europe PMC] [Abstract]
  51. "Characterization of a new DPB1 allele (DPB1*5701) isolated from a Caucasian individual."Tissue Antigens 46:208-212(1995) [PubMed] [Europe PMC] [Abstract]
  52. "The nucleotide sequence of two new DP alleles, DPA1*02015 and DPB1*8401, identified in a Chinese subject."Tissue Antigens 56:95-98(2000) [PubMed] [Europe PMC] [Abstract]
  53. "Genetic mapping of a human class II antigen beta-chain cDNA clone to the SB region of the HLA complex."Proc. Natl. Acad. Sci. U.S.A. 80:6036-6040(1983) [PubMed] [Europe PMC] [Abstract]
  54. "Invariant chain structure and MHC class II function."Cell 84:505-507(1996) [PubMed] [Europe PMC] [Abstract]
  55. "Presentation of antigens by MHC class II molecules: getting the most out of them."Mol. Immunol. 38:329-346(2001) [PubMed] [Europe PMC] [Abstract]
  56. "MHC class II molecules on the move for successful antigen presentation."EMBO J. 27:1-5(2008) [PubMed] [Europe PMC] [Abstract]
  57. "Autophagy in MHC class II presentation: sampling from within."Immunity 26:1-3(2007) [PubMed] [Europe PMC] [Abstract]
  58. "MHC class II transport at a glance."J. Cell Sci. 122:1-4(2009) [PubMed] [Europe PMC] [Abstract]
  59. "CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract."World J. Gastroenterol. 15:2855-2861(2009) [PubMed] [Europe PMC] [Abstract]