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Asialoglycoprotein Receptor 2 (ASGR2)

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CLEC4H2; Asialoglyco Protein Receptor 2; C-type lectin domain family 4 member H2; Hepatic lectin H2

Asialoglycoprotein Receptor 2 (ASGR2)
CCC C067
HGNC 743
MGI 88082
PubMed 1346401
RGD 2161
UniProt P07307
Wiki ASGR2

  • The ASGR2 gene encodes a glycoprotein that forms the asialoglycoprotein receptor, also known as the Ashwell receptor, which is specific for desialylated (galactosyl-terminal) glycoproteins and is expressed exclusively in hepatic parenchymal cells (Spiess and Lodish, 1985).From the same cDNA library that was made from the human hepatoma cell line HepG2 and was used to isolate ASGR1, Spiess and Lodish (1985) isolated and sequenced a clone encoding a second asialoglycoprotein receptor, which they referred to as H2 and which had protein sequence homology of 58% to H1.

  • The rat similarly has 2 ASG receptors, R1 and R2. Spiess and Lodish (1985) found that H1 is more homologous to R1 than to H2, and H2 is more homologous to R2 than to H1.

     

     

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC067Hu01 Recombinant Asialoglycoprotein Receptor 2 (ASGR2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC067Hu01 Polyclonal Antibody to Asialoglycoprotein Receptor 2 (ASGR2) WB; IHC; ICC; IP.
MAC067Hu22 Monoclonal Antibody to Asialoglycoprotein Receptor 2 (ASGR2) WB; IHC; ICC; IP.
Assay Kits SEC067Hu ELISA Kit for Asialoglycoprotein Receptor 2 (ASGR2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Asialoglycoprotein Receptor 2 (ASGR2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Asialoglycoprotein Receptor 2 (ASGR2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Asialoglycoprotein Receptor 2 (ASGR2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Asialoglycoprotein Receptor 2 (ASGR2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Asialoglycoprotein Receptor 2 (ASGR2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Asialoglycoprotein Receptor 2 (ASGR2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Asialoglycoprotein Receptor 2 (ASGR2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Asialoglycoprotein Receptor 2 (ASGR2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Asialoglycoprotein Receptor 2 (ASGR2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Asialoglycoprotein Receptor 2 (ASGR2) ELISA Kit Customized Service Offer
  1. "Sequence of a second human asialoglycoprotein receptor: conservation of two receptor genes during evolution."Proc. Natl. Acad. Sci. U.S.A. 82:6465-6469(1985) [PubMed] [Europe PMC] [Abstract]
  2. "Differences in the abundance of variably spliced transcripts for the second asialoglycoprotein receptor polypeptide, H2, in normal and transformed human liver."Hepatology 15:395-402(1992) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Cloning, mapping, and characterization of a human homologue of the yeast longevity assurance gene LAG1."Genomics 77:58-64(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]