≡

Dual Oxidase 2 (DUOX2)

[Edit]

LNOX2; NOXEF2; THOX2; Thyroid oxidase 2; NADH/NADPH thyroid oxidase p138-tox; Dual Oxidase-Like Domains 2; Nicotinamide Adenine Dinucleotide Phosphate Oxidase

Dual Oxidase 2 (DUOX2)
CCC C066
HGNC 13273
MGI 3036280
PubMed 18426362
RGD 628761
UniProt Q9NRD8
Wiki DUOX2

Dual oxidase is an enzyme that was first identified in the mammalian thyroid gland. In humans, two isoforms are found; hDUOX1 and hDUOX2 (this enzyme). The protein location is not exclusive to thyroid tissue; hDUOX1 is prominent in airway epithelial cells and hDUOX2 in the salivary glands and gastrointestinal tract.It has been suggested that DUOX2 is the isoform to generate H2O2 utilized by thyroid peroxidase (TPO) for the biosynthesis of thyroid hormones, supported by the discovery of congenital hypothyroidism resultant from an inactivating mutation in the DUOX2 gene. The family currently has seven members including NOX1, NOX2 (formerly known as gp91phox), NOX3, NOX4, NOX5, DUOX1 and DUOX2.This protein is known as a dual oxidase because it has both a peroxidase homology domain and a gp91phox domain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC066Hu01 Recombinant Dual Oxidase 2 (DUOX2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC066Hu01 Polyclonal Antibody to Dual Oxidase 2 (DUOX2) WB; IHC; ICC; IP.
MAC066Hu22 Monoclonal Antibody to Dual Oxidase 2 (DUOX2) WB; IHC; ICC; IP.
Assay Kits SEC066Hu ELISA Kit for Dual Oxidase 2 (DUOX2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dual Oxidase 2 (DUOX2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dual Oxidase 2 (DUOX2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dual Oxidase 2 (DUOX2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dual Oxidase 2 (DUOX2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dual Oxidase 2 (DUOX2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC066Ra01 Recombinant Dual Oxidase 2 (DUOX2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC066Ra01 Polyclonal Antibody to Dual Oxidase 2 (DUOX2) WB; IHC; ICC; IP.
MAC066Ra21 Monoclonal Antibody to Dual Oxidase 2 (DUOX2) WB; IHC; ICC; IP.
Assay Kits SEC066Ra ELISA Kit for Dual Oxidase 2 (DUOX2) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family."J. Biol. Chem. 275:23227-23233(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Tyrosine cross-linking of extracellular matrix is catalyzed by Duox, a multidomain oxidase/peroxidase with homology to the phagocyte oxidase subunit gp91phox."J. Cell Biol. 154:879-891(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  4. "Purification of a novel flavoprotein involved in the thyroid NADPH oxidase. Cloning of the porcine and human cDNAs."J. Biol. Chem. 274:37265-37269(1999) [PubMed] [Europe PMC] [Abstract]
  5. "Compound heterozygosity for a novel hemizygous missense mutation and a partial deletion affecting the catalytic core of the H2O2-generating enzyme DUOX2 associated with transient congenital hypothyroidism."Hum. Mutat. 31:E1304-E1319(2010) [PubMed] [Europe PMC] [Abstract]
  6. "Characterization of ThOX proteins as components of the thyroid H(2)O(2)-generating system."Exp. Cell Res. 273:187-196(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Inactivating mutations in the gene for thyroid oxidase 2 (THOX2) and congenital hypothyroidism."N. Engl. J. Med. 347:95-102(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defense."FASEB J. 17:1502-1504(2003) [PubMed] [Europe PMC] [Abstract]
  9. "NADPH oxidase-dependent acid production in airway epithelial cells."J. Biol. Chem. 279:36454-36461(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Dual oxidase2 is expressed all along the digestive tract."Am. J. Physiol. 288:G933-G942(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Identification of a novel partner of duox: EFP1, a thioredoxin-related protein."J. Biol. Chem. 280:3096-3103(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Dual oxidase-2 has an intrinsic Ca2+-dependent H2O2-generating activity."J. Biol. Chem. 280:30046-30054(2005) [PubMed] [Europe PMC] [Abstract]
  13. "Persistent mild hypothyroidism associated with novel sequence variants of the DUOX2 gene in two siblings."Hum. Mutat. 26:395-395(2005) [PubMed] [Europe PMC] [Abstract]
  14. "Three mutations (p.Q36H, p.G418fsX482, and g.IVS19-2A-->C) in the dual oxidase 2 gene responsible for congenital goiter and iodide organification defect."Clin. Chem. 52:182-191(2006) [PubMed] [Europe PMC] [Abstract]