≡

Platelet Derived Growth Factor Receptor Alpha (PDGFRa)

[Edit]

CD140a; PDGFR2; Rhe-PDGFRA; CD140 antigen-like family member A; Platelet-derived growth factor receptor 2; Alpha-type platelet-derived growth factor receptor

Platelet Derived Growth Factor Receptor Alpha (PDGFRa)
CCC C060
HGNC 8803
MGI 97530
PubMed 14699510
RGD 3284
UniProt P16234
Wiki PDGFRA

Alpha-type platelet-derived growth factor receptor is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides.

Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC060Hu01 Recombinant Platelet Derived Growth Factor Receptor Alpha (PDGFRa) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC060Hu01 Polyclonal Antibody to Platelet Derived Growth Factor Receptor Alpha (PDGFRa) WB; IHC; ICC; IP.
MAC060Hu22 Monoclonal Antibody to Platelet Derived Growth Factor Receptor Alpha (PDGFRa) WB; IHC; ICC; IP.
CAC060Hu22 Anti-Platelet Derived Growth Factor Receptor Alpha (PDGFRa) Monoclonal Antibody Loading Control of WB.
CAC060Hu01 Anti-Platelet Derived Growth Factor Receptor Alpha (PDGFRa) Polyclonal Antibody Loading Control of WB.
MAC060Hu21 Monoclonal Antibody to Platelet Derived Growth Factor Receptor Alpha (PDGFRa) WB; IHC; ICC; IP.
Assay Kits SEC060Hu ELISA Kit for Platelet Derived Growth Factor Receptor Alpha (PDGFRa) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Platelet Derived Growth Factor Receptor Alpha (PDGFRa) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Platelet Derived Growth Factor Receptor Alpha (PDGFRa) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Platelet Derived Growth Factor Receptor Alpha (PDGFRa) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Platelet Derived Growth Factor Receptor Alpha (PDGFRa) CLIA Kit Customized Service Offer
n/a ELISA Kit for Platelet Derived Growth Factor Receptor Alpha (PDGFRa) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC060Ra01 Recombinant Platelet Derived Growth Factor Receptor Alpha (PDGFRa) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC060Ra01 Polyclonal Antibody to Platelet Derived Growth Factor Receptor Alpha (PDGFRa) WB; IHC; ICC; IP.
MAC060Ra21 Monoclonal Antibody to Platelet Derived Growth Factor Receptor Alpha (PDGFRa) WB; IHC; ICC; IP.
Assay Kits SEC060Ra ELISA Kit for Platelet Derived Growth Factor Receptor Alpha (PDGFRa) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "cDNA cloning and expression of the human A-type platelet-derived growth factor (PDGF) receptor establishes structural similarity to the B-type PDGF receptor."Proc. Natl. Acad. Sci. U.S.A. 86:4917-4921(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes."Science 243:800-804(1989) [PubMed] [Europe PMC] [Abstract]
  3. "Structure, organization, and transcription units of the human alpha-platelet-derived growth factor receptor gene, PDGFRA."Genomics 30:224-232(1995) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Discovery of a fusion kinase in EOL-1 cells and idiopathic hypereosinophilic syndrome."Proc. Natl. Acad. Sci. U.S.A. 100:7830-7835(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Receptor tyrosine kinases expressed in metastatic colon cancer."Int. J. Cancer 60:791-797(1995) [PubMed] [Europe PMC] [Abstract]
  9. "Independent expression of human alpha or beta platelet-derived growth factor receptor cDNAs in a naive hematopoietic cell leads to functional coupling with mitogenic and chemotactic signaling pathways."Proc. Natl. Acad. Sci. U.S.A. 86:8314-8318(1989) [PubMed] [Europe PMC] [Abstract]
  10. "Binding of SH2 domains of phospholipase C gamma 1, GAP, and Src to activated growth factor receptors."Science 250:979-982(1990) [PubMed] [Europe PMC] [Abstract]
  11. "Platelet-derived growth factor (PDGF) stimulates PDGF receptor subunit dimerization and intersubunit trans-phosphorylation."J. Biol. Chem. 266:8987-8992(1991) [PubMed] [Europe PMC] [Abstract]
  12. "Tyrosine mutations within the alpha platelet-derived growth factor receptor kinase insert domain abrogate receptor-associated phosphatidylinositol-3 kinase activity without affecting mitogenic or chemotactic signal transduction."Mol. Cell. Biol. 11:3780-3785(1991) [PubMed] [Europe PMC] [Abstract]
  13. "Mechanism of platelet-derived growth factor (PDGF) AA, AB, and BB binding to alpha and beta PDGF receptor."J. Biol. Chem. 268:3625-3631(1993) [PubMed] [Europe PMC] [Abstract]
  14. "Negative feedback regulation of human platelets via autocrine activation of the platelet-derived growth factor alpha-receptor."J. Biol. Chem. 269:13874-13879(1994) [PubMed] [Europe PMC] [Abstract]
  15. "Demonstration of functionally different interactions between phospholipase C-gamma and the two types of platelet-derived growth factor receptors."J. Biol. Chem. 270:7773-7781(1995) [PubMed] [Europe PMC] [Abstract]
  16. "Maximal PDGF-induced lung fibroblast chemotaxis requires PDGF receptor-alpha."Am. J. Physiol. 271:L93-L99(1996) [PubMed] [Europe PMC] [Abstract]
  17. "Structural determinants in the platelet-derived growth factor alpha-receptor implicated in modulation of chemotaxis."J. Biol. Chem. 271:5101-5111(1996) [PubMed] [Europe PMC] [Abstract]
  18. "Grb7 is a downstream signaling component of platelet-derived growth factor alpha- and beta-receptors."J. Biol. Chem. 271:30942-30949(1996) [PubMed] [Europe PMC] [Abstract]
  19. "Phosphorylation of tyrosine 720 in the platelet-derived growth factor alpha receptor is required for binding of Grb2 and SHP-2 but not for activation of Ras or cell proliferation."Mol. Cell. Biol. 16:6926-6936(1996) [PubMed] [Europe PMC] [Abstract]
  20. "Differential interaction of CrkII adaptor protein with platelet-derived growth factor alpha- and beta-receptors is determined by its internal tyrosine phosphorylation."Biochem. Biophys. Res. Commun. 270:28-33(2000) [PubMed] [Europe PMC] [Abstract]
  21. "Shf, a Shb-like adapter protein, is involved in PDGF-alpha-receptor regulation of apoptosis."Biochem. Biophys. Res. Commun. 278:537-543(2000) [PubMed] [Europe PMC] [Abstract]
  22. "Platelet-derived-growth-factor-induced signalling in human platelets: phosphoinositide-3-kinase-dependent inhibition of platelet activation."Biochem. J. 350:469-475(2000) [PubMed] [Europe PMC] [Abstract]
  23. "Src family kinases negatively regulate platelet-derived growth factor alpha receptor-dependent signaling and disease progression."J. Biol. Chem. 275:9620-9627(2000) [PubMed] [Europe PMC] [Abstract]
  24. "Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha and beta receptor."J. Biol. Chem. 276:27406-27414(2001) [PubMed] [Europe PMC] [Abstract]
  25. "The role of c-Src in platelet-derived growth factor alpha receptor internalization."Exp. Cell Res. 291:426-434(2003) [PubMed] [Europe PMC] [Abstract]
  26. "A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome." N. Engl. J. Med. 348:1201-1214(2003) [PubMed] [Europe PMC] [Abstract]
  27. "PDGFRA activating mutations in gastrointestinal stromal tumors."Science 299:708-710(2003) [PubMed] [Europe PMC] [Abstract]
  28. "PDGFRA mutations in gastrointestinal stromal tumors: frequency, spectrum and in vitro sensitivity to imatinib."J. Clin. Oncol. 23:5357-5364(2005) [PubMed] [Europe PMC] [Abstract]
  29. "PI3-kinase/Akt-dependent antiapoptotic signaling by the PDGF alpha receptor is negatively regulated by Src family kinases."FEBS Lett. 580:6769-6776(2006) [PubMed] [Europe PMC] [Abstract]
  30. "Platelet-derived growth factor receptor-alpha: a novel therapeutic target in human hepatocellular cancer."Mol. Cancer Ther. 6:1932-1941(2007) [PubMed] [Europe PMC] [Abstract]
  31. "The glycoprotein B disintegrin-like domain binds beta 1 integrin to mediate cytomegalovirus entry."J. Virol. 84:10026-10037(2010) [PubMed] [Europe PMC] [Abstract]
  32. "Novel imatinib-sensitive PDGFRA-activating point mutations in hypereosinophilic syndrome induce growth factor independence and leukemia-like disease."Blood 117:2935-2943(2011) [PubMed] [Europe PMC] [Abstract]
  33. "The Casitas B lineage lymphoma (Cbl) mutant G306E enhances osteogenic differentiation in human mesenchymal stromal cells in part by decreased Cbl-mediated platelet-derived growth factor receptor alpha and fibroblast growth factor receptor 2 ubiquitination."J. Biol. Chem. 286:24443-24450(2011) [PubMed] [Europe PMC] [Abstract]
  34. "The low frequency of clinical resistance to PDGFR inhibitors in myeloid neoplasms with abnormalities of PDGFRA might be related to the limited repertoire of possible PDGFRA kinase domain mutations in vitro."Oncogene 30:933-943(2011) [PubMed] [Europe PMC] [Abstract]
  35. "Signal transduction via platelet-derived growth factor receptors."Biochim. Biophys. Acta 1378:F79-113(1998) [PubMed] [Europe PMC] [Abstract]
  36. "PDGF receptors-mediators of autocrine tumor growth and regulators of tumor vasculature and stroma."Cytokine Growth Factor Rev. 15:275-286(2004) [PubMed] [Europe PMC] [Abstract]
  37. "PDGF receptors as targets in tumor treatment."Adv. Cancer Res. 97:247-274(2007) [PubMed] [Europe PMC] [Abstract]
  38. "Role of platelet-derived growth factors in physiology and medicine."Genes Dev. 22:1276-1312(2008) [PubMed] [Europe PMC] [Abstract]
  39. "Structural determinants of the Na+/H+ exchanger regulatory factor interaction with the beta 2 adrenergic and platelet-derived growth factor receptors."J. Biol. Chem. 277:18973-18978(2002) [PubMed] [Europe PMC] [Abstract]
  40. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]