High Mobility Group AT Hook Protein 2 (HMGA2)
[Edit]BABL; HMGI-C; HMGIC; LIPO; High mobility group protein HMGI-C
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High mobility group AT-hook 2, also known as HMGA2, is a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with lipomas suggests a role in adipogenesis and mesenchymal differentiation.
A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC053Hu01 | Recombinant High Mobility Group AT Hook Protein 2 (HMGA2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAC053Hu01 | Polyclonal Antibody to High Mobility Group AT Hook Protein 2 (HMGA2) | WB; IHC; ICC; IP. |
| MAC053Hu22 | Monoclonal Antibody to High Mobility Group AT Hook Protein 2 (HMGA2) | WB; IHC; ICC; IP. | |
| LAC053Hu81 | FITC-Linked Polyclonal Antibody to High Mobility Group AT Hook Protein 2 (HMGA2) | WB; IHC; ICC; IF. | |
| LAC053Hu71 | Biotin-Linked Polyclonal Antibody to High Mobility Group AT Hook Protein 2 (HMGA2) | WB; IHC; ICC. | |
| Assay Kits | SEC053Hu | ELISA Kit for High Mobility Group AT Hook Protein 2 (HMGA2) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC053Mu01 | Recombinant High Mobility Group AT Hook Protein 2 (HMGA2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAC053Mu01 | Polyclonal Antibody to High Mobility Group AT Hook Protein 2 (HMGA2) | WB; IHC; ICC; IP. |
| LAC053Mu81 | FITC-Linked Polyclonal Antibody to High Mobility Group AT Hook Protein 2 (HMGA2) | WB; IHC; ICC; IF. | |
| LAC053Mu71 | Biotin-Linked Polyclonal Antibody to High Mobility Group AT Hook Protein 2 (HMGA2) | WB; IHC; ICC. | |
| Assay Kits | n/a | CLIA Kit for High Mobility Group AT Hook Protein 2 (HMGA2) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for High Mobility Group AT Hook Protein 2 (HMGA2) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant High Mobility Group AT Hook Protein 2 (HMGA2) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to High Mobility Group AT Hook Protein 2 (HMGA2) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to High Mobility Group AT Hook Protein 2 (HMGA2) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for High Mobility Group AT Hook Protein 2 (HMGA2) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for High Mobility Group AT Hook Protein 2 (HMGA2) | ELISA Kit Customized Service Offer |
- "Expression and cDNA cloning of human HMGI-C phosphoprotein."Biochem. Biophys. Res. Commun. 201:63-70(1994) [PubMed] [Europe PMC] [Abstract]
- "Recurrent rearrangements in the high mobility group protein gene, HMGI-C, in benign mesenchymal tumours."Nat. Genet. 10:436-444(1995) [PubMed] [Europe PMC] [Abstract]
- "The gene for the human architectural transcription factor HMGI-C consists of five exons each coding for a distinct functional element."Nucleic Acids Res. 23:4262-4266(1995) [PubMed] [Europe PMC] [Abstract]
- "Genomic characterization of human HMGIC, a member of the accessory transcription factor family found at translocation breakpoints in lipomas."Genomics 31:207-214(1996) [PubMed] [Europe PMC] [Abstract]
- "Extensive expression studies revealed a complex alternative splicing pattern of the HMGA2 gene."Biochim. Biophys. Acta 1729:24-31(2005) [PubMed] [Europe PMC] [Abstract]
- "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]