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High Mobility Group Box Protein 2 (HMGB2)

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HMG2

High Mobility Group Box Protein 2 (HMGB2)
CCC C052
HGNC 5000
MGI 96157
PubMed 23495099
RGD 69291
UniProt P26583
Wiki HMGB2

High mobility group protein B2 is  a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility.

This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC052Hu01 Recombinant High Mobility Group Box Protein 2 (HMGB2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC052Hu01 Polyclonal Antibody to High Mobility Group Box Protein 2 (HMGB2) WB
Assay Kits n/a CLIA Kit for High Mobility Group Box Protein 2 (HMGB2) CLIA Kit Customized Service Offer
n/a ELISA Kit for High Mobility Group Box Protein 2 (HMGB2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant High Mobility Group Box Protein 2 (HMGB2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to High Mobility Group Box Protein 2 (HMGB2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to High Mobility Group Box Protein 2 (HMGB2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for High Mobility Group Box Protein 2 (HMGB2) CLIA Kit Customized Service Offer
n/a ELISA Kit for High Mobility Group Box Protein 2 (HMGB2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC052Ra01 Recombinant High Mobility Group Box Protein 2 (HMGB2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to High Mobility Group Box Protein 2 (HMGB2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to High Mobility Group Box Protein 2 (HMGB2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for High Mobility Group Box Protein 2 (HMGB2) CLIA Kit Customized Service Offer
n/a ELISA Kit for High Mobility Group Box Protein 2 (HMGB2) ELISA Kit Customized Service Offer
  1. "Sequence of human HMG2 cDNA."Nucleic Acids Res. 19:6643-6643(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Structure of a gene coding for human HMG2 protein."J. Biol. Chem. 267:6641-6645(1992) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "A human HMG2 cDNA with a novel 3'-untranslated region."Nucleic Acids Res. 20:6413-6413(1992) [PubMed] [Europe PMC] [Abstract]
  6. "HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A."Mol. Cell. Biol. 22:2810-2820(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]