Growth Differentiation Factor 15 (GDF15)
[Edit]PDF; MIC1; NAG-1; PLAB; PTGFB; Macrophage inhibitory cytokine 1; NSAID-activated gene 1 protein; Placental bone morphogenetic protein; Prostate differentiation factor
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GDF15 is a protein belonging to the transforming growth factor beta superfamily that has a role in regulating inflammatory and apoptotic pathways in injured tissues and during disease processes.GDF15 is also known as TGF-PL, MIC-1, PDF, PLAB, and PTGFB.GDF15 mRNA is most abundant in the liver, with lower levels seen in some other tissues. Its expression in liver can be significantly up-regulated in during injury of organs such as liver, kidney, heart and lung.
Northern blot analysis showed that MIC1 is not expressed in undifferentiated cells but is progressively upregulated upon differentiation with retinoic acid followed by phorbol ester or cytokine treatment. Exposure of macrophages to MIC1 or TGFB1, followed by stimulation with lipopolysaccharide, suppressed the production of TNFA.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC034Mu01 | Recombinant Growth Differentiation Factor 15 (GDF15) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPC034Mu02 | Recombinant Growth Differentiation Factor 15 (GDF15) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAC034Mu01 | Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) | WB; IHC; ICC; IP. |
| LAC034Mu71 | Biotin-Linked Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) | WB; IHC; ICC. | |
| LAC034Mu81 | FITC-Linked Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) | WB; IHC; ICC; IF. | |
| PAC034Mu02 | Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) | WB; IHC; ICC; IP. | |
| Assay Kits | SEC034Mu | ELISA Kit for Growth Differentiation Factor 15 (GDF15) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCC034Mu | CLIA Kit for Growth Differentiation Factor 15 (GDF15) | Chemiluminescent immunoassay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC034Ra01 | Recombinant Growth Differentiation Factor 15 (GDF15) | Positive Control; Immunogen; SDS-PAGE; WB. |
| APC034Ra01 | Active Growth Differentiation Factor 15 (GDF15) | Cell culture; Activity Assays. | |
| Antibodies | PAC034Ra01 | Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) | WB; IHC; ICC; IP. |
| LAC034Ra71 | Biotin-Linked Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) | WB; IHC; ICC. | |
| MAC034Ra21 | Monoclonal Antibody to Growth Differentiation Factor 15 (GDF15) | WB; IHC; ICC; IP. | |
| Assay Kits | SEC034Ra | ELISA Kit for Growth Differentiation Factor 15 (GDF15) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCC034Ra | CLIA Kit for Growth Differentiation Factor 15 (GDF15) | Chemiluminescent immunoassay for Antigen Detection. |
Organism species: Rhesus monkey (Simian)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC034Si01 | Recombinant Growth Differentiation Factor 15 (GDF15) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | n/a | Monoclonal Antibody to Growth Differentiation Factor 15 (GDF15) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | SEC034Si | ELISA Kit for Growth Differentiation Factor 15 (GDF15) | Enzyme-linked immunosorbent assay for Antigen Detection. |
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