Interleukin 35 (IL35)

Interleukin 35 (IL-35) is an IL-12 family cytokine that is produced by regulatory, but not effector, T cells and plays a role in immune suppression. It is a dimeric protein composed of IL-12alpha; and IL-27beta; chains, which are encoded by two separate genes called IL12A and EBI3, respectively.

Secreted by regulatory T cells (Tregs), IL-35 suppresses inflammatory responses of immune cells. Studies in mice show the absence of either IL-35 chain from regulatory Tregs reduces the cells ability to suppress inflammation; this has been observed during cell culture experiments and using an experimental model for inflammatory bowel disease. To produce its suppressive effects, IL-35 has selective activities on different T cell subsets; it induces proliferation of Treg cell populations but reduces activity of Th17 cell populations.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC008Hu01 Recombinant Interleukin 35 (IL35) Positive Control; Immunogen; SDS-PAGE; WB.
APC008Hu01 Active Interleukin 35 (IL35) Cell culture; Activity Assays.
Antibodies PAC008Hu01 Polyclonal Antibody to Interleukin 35 (IL35) WB; IHC
MAC008Hu21 Monoclonal Antibody to Interleukin 35 (IL35) WB; IHC; ICC; IP.
LAC008Hu72 Biotin-Linked Monoclonal Antibody to Interleukin 35 (IL35) WB; IHC; ICC.
MAC008Hu25 Monoclonal Antibody to Interleukin 35 (IL35) WB
MAC008Hu22 Monoclonal Antibody to Interleukin 35 (IL35) WB
MAC008Hu23 Monoclonal Antibody to Interleukin 35 (IL35) WB
MAC008Hu24 Monoclonal Antibody to Interleukin 35 (IL35) WB
MAC008Hu27 Monoclonal Antibody to Interleukin 35 (IL35) WB
MAC008Hu26 Monoclonal Antibody to Interleukin 35 (IL35) WB; IHC; ICC; IP.
MAC008Hu29 Monoclonal Antibody to Interleukin 35 (IL35) WB; IHC; ICC; IP.
MAC008Hu28 Monoclonal Antibody to Interleukin 35 (IL35) WB; IHC; ICC; IP.
Assay Kits SEC008Hu ELISA Kit for Interleukin 35 (IL35) Enzyme-linked immunosorbent assay for Antigen Detection.
HEC008Hu High Sensitive ELISA Kit for Interleukin 35 (IL35) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC008Mu01 Recombinant Interleukin 35 (IL35) Positive Control; Immunogen; SDS-PAGE; WB.
RPC008Mu02 Recombinant Interleukin 35 (IL35) Positive Control; Immunogen; SDS-PAGE; WB.
APC008Mu01 Active Interleukin 35 (IL35) Cell culture; Activity Assays.
Antibodies PAC008Mu01 Polyclonal Antibody to Interleukin 35 (IL35) WB; IHC; ICC; IP.
Assay Kits SEC008Mu ELISA Kit for Interleukin 35 (IL35) Enzyme-linked immunosorbent assay for Antigen Detection.
SCC008Mu CLIA Kit for Interleukin 35 (IL35) Chemiluminescent immunoassay for Antigen Detection.