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Arrestin Beta 2 (ARRb2)

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ARB2; ARR2; ARR-B2; Arrestin 3

Arrestin Beta 2 (ARRb2)
CCC B994
HGNC 712
MGI 99474
PubMed 22472784
RGD 2157
UniProt P32121
Wiki ARRB2

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals,as well as having signalling roles in their own right.Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB994Hu01 Recombinant Arrestin Beta 2 (ARRb2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB994Hu01 Polyclonal Antibody to Arrestin Beta 2 (ARRb2) WB; IHC; ICC; IP.
MAB994Hu22 Monoclonal Antibody to Arrestin Beta 2 (ARRb2) WB; IHC; ICC; IP.
Assay Kits SEB994Hu ELISA Kit for Arrestin Beta 2 (ARRb2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Arrestin Beta 2 (ARRb2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Arrestin Beta 2 (ARRb2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Arrestin Beta 2 (ARRb2) Polyclonal Antibody Customized Service Offer
Assay Kits SEB994Mu ELISA Kit for Arrestin Beta 2 (ARRb2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Arrestin Beta 2 (ARRb2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Arrestin Beta 2 (ARRb2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Arrestin Beta 2 (ARRb2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Arrestin Beta 2 (ARRb2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Arrestin Beta 2 (ARRb2) ELISA Kit Customized Service Offer
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  9. "Molecular determinants underlying the formation of stable intracellular G protein-coupled receptor-beta-arrestin complexes after receptor endocytosis*."J. Biol. Chem. 276:19452-19460(2001) [PubMed] [Europe PMC] [Abstract]
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  12. "Desensitization, internalization, and signaling functions of beta-arrestins demonstrated by RNA interference."Proc. Natl. Acad. Sci. U.S.A. 100:1740-1744(2003) [PubMed] [Europe PMC] [Abstract]
  13. "Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2."Proc. Natl. Acad. Sci. U.S.A. 100:10782-10787(2003) [PubMed] [Europe PMC] [Abstract]
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  19. "Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2."Science 306:2257-2260(2004) [PubMed] [Europe PMC] [Abstract]
  20. "{beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase."J. Biol. Chem. 280:24412-24419(2005) [PubMed] [Europe PMC] [Abstract]
  21. "Dynamic interaction between the dual specificity phosphatase MKP7 and the JNK3 scaffold protein beta-arrestin 2."J. Biol. Chem. 280:25651-25658(2005) [PubMed] [Europe PMC] [Abstract]
  22. "G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers."J. Biol. Chem. 280:37503-37515(2005) [PubMed] [Europe PMC] [Abstract]
  23. "Multiple independent functions of arrestins in the regulation of protease-activated receptor-2 signaling and trafficking."Mol. Pharmacol. 67:78-87(2005) [PubMed] [Europe PMC] [Abstract]
  24. "Beta-arrestin 2-dependent angiotensin II type 1A receptor-mediated pathway of chemotaxis."Mol. Pharmacol. 67:1229-1236(2005) [PubMed] [Europe PMC] [Abstract]
  25. "Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor."Proc. Natl. Acad. Sci. U.S.A. 102:1448-1453(2005) [PubMed] [Europe PMC] [Abstract]
  26. "beta-Arrestins bind and decrease cell-surface abundance of the Na+/H+ exchanger NHE5 isoform."Proc. Natl. Acad. Sci. U.S.A. 102:2790-2795(2005) [PubMed] [Europe PMC] [Abstract]
  27. "Molecular switches involving the AP-2 beta2 appendage regulate endocytic cargo selection and clathrin coat assembly."Dev. Cell 10:329-342(2006) [PubMed] [Europe PMC] [Abstract]
  28. "beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor."J. Biol. Chem. 281:1261-1273(2006) [PubMed] [Europe PMC] [Abstract]
  29. "A beta-arrestin binding determinant common to the second intracellular loops of rhodopsin family G protein-coupled receptors."J. Biol. Chem. 281:2932-2938(2006) [PubMed] [Europe PMC] [Abstract]
  30. "Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation."J. Biol. Chem. 281:10856-10864(2006) [PubMed] [Europe PMC] [Abstract]
  31. "Novel function of beta-arrestin2 in the nucleus of mature spermatozoa."J. Cell Sci. 119:3047-3056(2006) [PubMed] [Europe PMC] [Abstract]
  32. "Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling."Nat. Immunol. 7:139-147(2006) [PubMed] [Europe PMC] [Abstract]
  33. "The melanosomal/lysosomal protein OA1 has properties of a G protein-coupled receptor."Pigment Cell Res. 19:125-135(2006) [PubMed] [Europe PMC] [Abstract]
  34. "The interaction of endoglin with beta-arrestin2 regulates transforming growth factor-beta-mediated ERK activation and migration in endothelial cells."J. Biol. Chem. 282:21507-21517(2007) [PubMed] [Europe PMC] [Abstract]
  35. "Post-endocytic fates of delta-opioid receptor are regulated by GRK2-mediated receptor phosphorylation and distinct beta-arrestin isoforms."J. Neurochem. 106:781-792(2008) [PubMed] [Europe PMC] [Abstract]
  36. "An essential function for beta-arrestin 2 in the inhibitory signaling of natural killer cells."Nat. Immunol. 9:898-907(2008) [PubMed] [Europe PMC] [Abstract]
  37. "The type III transforming growth factor-beta receptor negatively regulates nuclear factor kappa B signaling through its interaction with beta-arrestin2."Carcinogenesis 30:1281-1287(2009) [PubMed] [Europe PMC] [Abstract]
  38. "Inhibition of dynamin prevents CCL2-mediated endocytosis of CCR2 and activation of ERK1/2."Cell. Signal. 21:1748-1757(2009) [PubMed] [Europe PMC] [Abstract]
  39. "A scanning peptide array approach uncovers association sites within the JNK/beta arrestin signalling complex."FEBS Lett. 583:3310-3316(2009) [PubMed] [Europe PMC] [Abstract]
  40. "An arrestin-dependent multi-kinase signaling complex mediates MIP-1beta/CCL4 signaling and chemotaxis of primary human macrophages."J. Leukoc. Biol. 86:833-845(2009) [PubMed] [Europe PMC] [Abstract]
  41. "Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2."Proc. Natl. Acad. Sci. U.S.A. 106:6650-6655(2009) [PubMed] [Europe PMC] [Abstract]
  42. "Site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signaling."J. Biol. Chem. 285:7805-7817(2010) [PubMed] [Europe PMC] [Abstract]
  43. "Prolyl hydroxylase 2: a novel regulator of beta2 -adrenoceptor internalization."J. Cell. Mol. Med. 15:2712-2722(2011) [PubMed] [Europe PMC] [Abstract]
  44. "Carboxy-terminus of CXCR7 regulates receptor localization and function."Int. J. Biochem. Cell Biol. 44:669-678(2012) [PubMed] [Europe PMC] [Abstract]
  45. "Ubiquitination of CXCR7 controls receptor trafficking."PLoS ONE 7:E34192-E34192(2012) [PubMed] [Europe PMC] [Abstract]
  46. "Beta-arrestin recruitment and G protein signaling by the atypical human chemokine decoy receptor CCX-CKR."J. Biol. Chem. 288:7169-7181(2013) [PubMed] [Europe PMC] [Abstract]