≡

Toll Like Receptor 8 (TLR8)

[Edit]

CD288

Toll Like Receptor 8 (TLR8)
CCC B991
HGNC 15632
MGI 2176887
PubMed 19637197
UniProt Q9NR97
Wiki TLR8

Toll-like receptor 8 is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity.

The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X.TLR8 recognises G-rich oligonucleotides.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB991Hu01 Recombinant Toll Like Receptor 8 (TLR8) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB991Hu01 Polyclonal Antibody to Toll Like Receptor 8 (TLR8) WB,IHC,ICC/IF
MAB991Hu22 Monoclonal Antibody to Toll Like Receptor 8 (TLR8) WB; IHC; ICC; IP.
LAB991Hu71 Biotin-Linked Polyclonal Antibody to Toll Like Receptor 8 (TLR8) WB; IHC; ICC.
LAB991Hu81 FITC-Linked Polyclonal Antibody to Toll Like Receptor 8 (TLR8) WB; IHC; ICC; IF.
MAB991Hu21 Monoclonal Antibody to Toll Like Receptor 8 (TLR8) WB; IHC; ICC; IP.
Assay Kits SEB991Hu ELISA Kit for Toll Like Receptor 8 (TLR8) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Toll Like Receptor 8 (TLR8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Toll Like Receptor 8 (TLR8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Toll Like Receptor 8 (TLR8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Toll Like Receptor 8 (TLR8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Toll Like Receptor 8 (TLR8) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB991Ra01 Recombinant Toll Like Receptor 8 (TLR8) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB991Ra01 Polyclonal Antibody to Toll Like Receptor 8 (TLR8) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Toll Like Receptor 8 (TLR8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Toll Like Receptor 8 (TLR8) ELISA Kit Customized Service Offer
  1. "Three novel mammalian Toll-like receptors: gene structure, expression, and evolution."Eur. Cytokine Netw. 11:362-371(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and characterization of a sub-family of human Toll-like receptors: hTLR7, hTLR8 and hTLR9."Eur. Cytokine Netw. 11:372-378(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Natural selection in the TLR-related genes in the course of primate evolution."Immunogenetics 60:727-735(2008) [PubMed] [Europe PMC] [Abstract]
  4. "The heterogeneous allelic repertoire of human Toll-Like receptor (TLR) genes."PLoS ONE 4:E7803-E7803(2009) [PubMed] [Europe PMC] [Abstract]
  5. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase."J. Biol. Chem. 282:36953-36960(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands."Science 339:1426-1429(2013) [PubMed] [Europe PMC] [Abstract]