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Toll Like Receptor 3 (TLR3)

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CD283

Toll Like Receptor 3 (TLR3)
CCC B989
HGNC 11849
MGI 2156367
PubMed 15733829
RGD 735171
UniProt O15455
Wiki TLR_3

TLR 3 is a member of the Toll-like receptor family of pattern recognition receptors of the innate immune system. Discovered in 2001,TLR3 recognizes double-stranded RNA, a form of genetic information carried by some viruses such as reoviruses. Upon recognition, TLR 3 induces the activation of NF-kB to increase production of type I interferons which signal other cells to increase their antiviral defenses.

Double-stranded RNA is also recognised by the cytoplasmic receptors RIG-I and MDA-5.The structure of TLR3 was reported in June 2005 by researchers at The Scripps Research Institute. TLR3 forms a large horseshoe shape that contacts with a neighboring horseshoe, forming a "dimer" of two horseshoes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB989Hu01 Recombinant Toll Like Receptor 3 (TLR3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB989Hu01 Polyclonal Antibody to Toll Like Receptor 3 (TLR3) WB; IHC; ICC; IP.
MAB989Hu22 Monoclonal Antibody to Toll Like Receptor 3 (TLR3) WB; IHC; ICC; IP.
LAB989Hu71 Biotin-Linked Polyclonal Antibody to Toll Like Receptor 3 (TLR3) WB; IHC; ICC.
LAB989Hu81 FITC-Linked Polyclonal Antibody to Toll Like Receptor 3 (TLR3) WB; IHC; ICC; IF.
MAB989Hu21 Monoclonal Antibody to Toll Like Receptor 3 (TLR3) WB; IHC; ICC; IP.
Assay Kits SEB989Hu ELISA Kit for Toll Like Receptor 3 (TLR3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB989Mu01 Recombinant Toll Like Receptor 3 (TLR3) Positive Control; Immunogen; SDS-PAGE; WB.
RPB989Mu02 Recombinant Toll Like Receptor 3 (TLR3) Positive Control; Immunogen; SDS-PAGE; WB.
RPB989Mu03 Recombinant Toll Like Receptor 3 (TLR3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB989Mu01 Polyclonal Antibody to Toll Like Receptor 3 (TLR3) WB; IHC; ICC; IP.
PAB989Mu02 Polyclonal Antibody to Toll Like Receptor 3 (TLR3) WB; IHC; ICC; IP.
LAB989Mu71 Biotin-Linked Polyclonal Antibody to Toll Like Receptor 3 (TLR3) WB; IHC; ICC.
PAB989Mu03 Polyclonal Antibody to Toll Like Receptor 3 (TLR3) WB; IHC; ICC; IP.
Assay Kits SEB989Mu ELISA Kit for Toll Like Receptor 3 (TLR3) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB989Mu CLIA Kit for Toll Like Receptor 3 (TLR3) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB989Ra01 Recombinant Toll Like Receptor 3 (TLR3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB989Ra01 Polyclonal Antibody to Toll Like Receptor 3 (TLR3) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Toll Like Receptor 3 (TLR3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Toll Like Receptor 3 (TLR3) ELISA Kit Customized Service Offer
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  10. "Recognition of double-stranded RNA by human toll-like receptor 3 and downstream receptor signaling requires multimerization and an acidic pH."J. Biol. Chem. 280:38133-38145(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Toll-like receptor 3 associates with c-Src tyrosine kinase on endosomes to initiate antiviral signaling."EMBO J. 25:3335-3346(2006) [PubMed] [Europe PMC] [Abstract]
  12. "The dsRNA binding site of human Toll-like receptor 3."Proc. Natl. Acad. Sci. U.S.A. 103:8792-8797(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Two tyrosine residues of Toll-like receptor 3 trigger different steps of NF-kappa B activation."J. Biol. Chem. 282:3423-3427(2007) [PubMed] [Europe PMC] [Abstract]
  14. "The TLR3 signaling complex forms by cooperative receptor dimerization."Proc. Natl. Acad. Sci. U.S.A. 105:258-263(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Cleavage of Toll-like receptor 3 by cathepsins B and H is essential for signaling."Proc. Natl. Acad. Sci. U.S.A. 109:9053-9058(2012) [PubMed] [Europe PMC] [Abstract]
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  18. "Crystal structure of human toll-like receptor 3 (TLR3) ectodomain."Science 309:581-585(2005) [PubMed] [Europe PMC] [Abstract]
  19. "Lateral clustering of TLR3:dsRNA signaling units revealed by TLR3ecd:3Fabs quaternary structure."J. Mol. Biol. 421:112-124(2012) [PubMed] [Europe PMC] [Abstract]
  20. "TLR3 deficiency in patients with herpes simplex encephalitis." Science 317:1522-1527(2007) [PubMed] [Europe PMC] [Abstract]
  21. "Toll-like receptor 3 and geographic atrophy in age-related macular degeneration." N. Engl. J. Med. 359:1456-1463(2008) [PubMed] [Europe PMC] [Abstract]
  22. Erratum N. Engl. J. Med. 359:1859-1859(2008)
  23. "A common polymorphism in TLR3 confers natural resistance to HIV-1 infection."J. Immunol. 188:818-823(2012) [PubMed] [Europe PMC] [Abstract]