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Sodium Hydrogen Exchange Regulatory Cofactor 2 (SLC9A3R2)

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TKA1; SIP1; E3KARP; NHERF2; OCTS2; SRY-interacting protein 1; Solute Carrier Family 9 Member 3 Regulator 2; Tyrosine Kinase Activator Protein 1

Sodium Hydrogen Exchange Regulatory Cofactor 2 (SLC9A3R2)
CCC B976
HGNC 11076
MGI 1890662
PubMed 21457650
RGD 620380
UniProt Q15599
Wiki SLC9A3R2

Tyrosine kinase activator protein 1 is a human scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. It is necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May also act as scaffold protein in the nucleus.
This regulatory protein (factor) interacts with a sodium/hydrogen exchanger NHE3 (SLC9A3) in the brush border membrane of the proximal tubule, small intestine, and colon that plays a major role in transepithelial sodium absorption. SLC9A3R2, as well as SLC9A3R1 and protein kinase A phosphorylation, may play a role in NHE3 regulation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB976Hu01 Recombinant Sodium Hydrogen Exchange Regulatory Cofactor 2 (SLC9A3R2) Positive Control; Immunogen; SDS-PAGE; WB.
RPB976Hu02 Recombinant Sodium Hydrogen Exchange Regulatory Cofactor 2 (SLC9A3R2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB976Hu01 Polyclonal Antibody to Sodium Hydrogen Exchange Regulatory Cofactor 2 (SLC9A3R2) WB; IHC; ICC; IP.
PAB976Hu02 Polyclonal Antibody to Sodium Hydrogen Exchange Regulatory Cofactor 2 (SLC9A3R2) WB; IHC; ICC; IP.
Assay Kits SEB976Hu ELISA Kit for Sodium Hydrogen Exchange Regulatory Cofactor 2 (SLC9A3R2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sodium Hydrogen Exchange Regulatory Cofactor 2 (SLC9A3R2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sodium Hydrogen Exchange Regulatory Cofactor 2 (SLC9A3R2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sodium Hydrogen Exchange Regulatory Cofactor 2 (SLC9A3R2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sodium Hydrogen Exchange Regulatory Cofactor 2 (SLC9A3R2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sodium Hydrogen Exchange Regulatory Cofactor 2 (SLC9A3R2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sodium Hydrogen Exchange Regulatory Cofactor 2 (SLC9A3R2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sodium Hydrogen Exchange Regulatory Cofactor 2 (SLC9A3R2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sodium Hydrogen Exchange Regulatory Cofactor 2 (SLC9A3R2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sodium Hydrogen Exchange Regulatory Cofactor 2 (SLC9A3R2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sodium Hydrogen Exchange Regulatory Cofactor 2 (SLC9A3R2) ELISA Kit Customized Service Offer
  1. "The human testis determining factor SRY binds a nuclear factor containing PDZ protein interaction domains."J. Biol. Chem. 272:7167-7172(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of EBP50: a PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin family."J. Cell Biol. 139:169-179(1997) [PubMed] [Europe PMC] [Abstract]
  3. "cAMP-mediated inhibition of the epithelial brush border Na+/H+ exchanger, NHE3, requires an associated regulatory protein."Proc. Natl. Acad. Sci. U.S.A. 94:3010-3015(1997) [PubMed] [Europe PMC] [Abstract]
  4. "Genomic structure and sequence of a human homologue (NTHL1/NTH1) of Escherichia coli endonuclease III with those of the adjacent parts of TSC2 and SLC9A3R2 genes."Gene 222:287-295(1998) [PubMed] [Europe PMC] [Abstract]
  5. "A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins."Proc. Natl. Acad. Sci. U.S.A. 95:8496-8501(1998) [PubMed] [Europe PMC] [Abstract]
  6. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "cAMP-induced phosphorylation and inhibition of Na(+)/H(+) exchanger 3 (NHE3) are dependent on the presence but not the phosphorylation of NHE regulatory factor."J. Biol. Chem. 274:24753-24758(1999) [PubMed] [Europe PMC] [Abstract]
  9. "Isoforms of SLC26A6 mediate anion transport and have functional PDZ interaction domains."Am. J. Physiol. 284:C769-C779(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Molecular requirements for the regulation of the renal outer medullary K(+) channel ROMK1 by the serum- and glucocorticoid-inducible kinase SGK1."Biochem. Biophys. Res. Commun. 311:629-634(2003) [PubMed] [Europe PMC] [Abstract]
  11. "NHERF2 specifically interacts with LPA2 receptor and defines the specificity and efficiency of receptor-mediated phospholipase C-beta3 activation."Mol. Cell. Biol. 24:5069-5079(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Gp135/podocalyxin and NHERF-2 participate in the formation of a preapical domain during polarization of MDCK cells."J. Cell Biol. 168:303-313(2005) [PubMed] [Europe PMC] [Abstract]
  13. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  14. "MCC, a new interacting protein for Scrib, is required for cell migration in epithelial cells."FEBS Lett. 583:2326-2332(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  17. "Structural basis for NHERF recognition by ERM proteins."Structure 14:777-789(2006) [PubMed] [Europe PMC] [Abstract]
  18. "The crystal structure of the first and second PDZ domain of human NHERF-2 (SLC9A3R2) interacting with a mode 1 PDZ binding motif."Submitted (JAN-2007) to the PDB data bank