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Dynamin 1 (DNM1)

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Dynamin 1 (DNM1)
CCC B962
HGNC 2972
MGI 107384
PubMed 20127811
RGD 71096
UniProt Q05193
Wiki DNM1

Dynamin-1 is a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity.

More than sixty highly conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB962Hu01 Recombinant Dynamin 1 (DNM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB962Hu01 Polyclonal Antibody to Dynamin 1 (DNM1) WB; IHC; ICC; IP.
MAB962Hu22 Monoclonal Antibody to Dynamin 1 (DNM1) WB; IHC; ICC; IP.
Assay Kits SEB962Hu ELISA Kit for Dynamin 1 (DNM1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB962Mu01 Recombinant Dynamin 1 (DNM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB962Mu01 Polyclonal Antibody to Dynamin 1 (DNM1) WB,IHC
Assay Kits n/a CLIA Kit for Dynamin 1 (DNM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dynamin 1 (DNM1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dynamin 1 (DNM1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dynamin 1 (DNM1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dynamin 1 (DNM1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dynamin 1 (DNM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dynamin 1 (DNM1) ELISA Kit Customized Service Offer
  1. "Mutations in human dynamin block an intermediate stage in coated vesicle formation."J. Cell Biol. 122:553-563(1993) [PubMed] [Europe PMC] [Abstract]
  2. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "SNX9 regulates dynamin assembly and is required for efficient clathrin-mediated endocytosis."Mol. Biol. Cell 16:2058-2067(2005) [PubMed] [Europe PMC] [Abstract]
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Myosin 1E interacts with synaptojanin-1 and dynamin and is involved in endocytosis."FEBS Lett. 581:644-650(2007) [PubMed] [Europe PMC] [Abstract]
  7. "A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein."J. Biol. Chem. 283:14257-14268(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Three-dimensional solution structure of the pleckstrin homology domain from dynamin."Curr. Biol. 4:884-891(1994) [PubMed] [Europe PMC] [Abstract]
  11. "Crystal structure at 2.2-A resolution of the pleckstrin homology domain from human dynamin."Cell 79:199-209(1994) [PubMed] [Europe PMC] [Abstract]
  12. "Crystal structure of the pleckstrin homology domain from dynamin."Nat. Struct. Biol. 1:782-788(1994) [PubMed] [Europe PMC] [Abstract]