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Immunoglobulin D (IgD)

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IGHD; Constant Region Of Heavy Chain Of Immunoglobulin Delta

Immunoglobulin D (IgD)
CCC B941
HGNC 5480
PubMed 20727035
UniProt P01880
Wiki IgD

Immunoglobulin D (IgD) is an antibody isotype that makes up about 1% of proteins in the plasma membranes of immature B-lymphocytes where it is usually coexpressed with another cell surface antibody called IgM. IgD is also produced in a secreted form that is found in very small amounts in blood serum. Secreted IgD is produced as a monomeric antibody with two heavy chains of the delta (delta) class, and two Ig light chains. IgD's function has always been a puzzle in immunology since its discovery in 1964. IgD was recently found to be present in species from cartilaginous fish to human (probably with the exception of birds) Reference. This nearly ubiquitous appearance in species with an adaptive immune system demonstrates that IgD is as ancient as IgM and suggests the notion that IgD has important immunological functions.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NPB941Hu01 Native Immunoglobulin D (IgD) Positive Control; Immunogen; SDS-PAGE; WB.
RPB941Hu01 Recombinant Immunoglobulin D (IgD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB941Hu01 Polyclonal Antibody to Immunoglobulin D (IgD) WB; IHC; ICC; IP.
MAB941Hu22 Monoclonal Antibody to Immunoglobulin D (IgD) WB; IHC; ICC; IP.
Assay Kits SCB941Hu CLIA Kit for Immunoglobulin D (IgD) Chemiluminescent immunoassay for Antigen Detection.
CEB941Hu ELISA Kit for Immunoglobulin D (IgD) Enzyme-linked immunosorbent assay for Antigen Detection.
SEB941Hu ELISA Kit for Immunoglobulin D (IgD) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Immunoglobulin D (IgD) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Immunoglobulin D (IgD) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Immunoglobulin D (IgD) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Immunoglobulin D (IgD) CLIA Kit Customized Service Offer
n/a ELISA Kit for Immunoglobulin D (IgD) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB941Ra01 Recombinant Immunoglobulin D (IgD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB941Ra01 Polyclonal Antibody to Immunoglobulin D (IgD) WB,IHC
Assay Kits CEB941Ra ELISA Kit for Immunoglobulin D (IgD) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Human immunoglobulin D: genomic sequence of the delta heavy chain."Science 228:733-737(1985) [PubMed] [Europe PMC] [Abstract]
  2. "The human immunoglobulin C mu-C delta locus: complete nucleotide sequence and structural analysis."Int. Immunol. 1:296-309(1989) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Amino acid sequence of the first constant region domain and the hinge region of the delta heavy chain of human IgD."Proc. Natl. Acad. Sci. U.S.A. 78:6168-6172(1981) [PubMed] [Europe PMC] [Abstract]
  5. "Primary structure of the Fc region of human immunoglobulin D: implications for evolutionary origin and biological function."Proc. Natl. Acad. Sci. U.S.A. 78:504-508(1981) [PubMed] [Europe PMC] [Abstract]
  6. "Amino acid sequence of galactosamine-containing glycopeptides in the hinge region of a human immunoglobulin D."Biochem. Biophys. Res. Commun. 105:1066-1071(1982) [PubMed] [Europe PMC] [Abstract]
  7. "Complete amino acid sequence of the Fc region of a human delta chain."Proc. Natl. Acad. Sci. U.S.A. 78:785-789(1981) [PubMed] [Europe PMC] [Abstract]
  8. "Immunoglobulin D enhances the release of tumor necrosis factor-alpha, and interleukin-1 beta as well as interleukin-1 receptor antagonist from human mononuclear cells."Immunology 88:355-362(1996) [PubMed] [Europe PMC] [Abstract]
  9. "Immunoglobulin D: properties, measurement, and clinical relevance."Clin. Diagn. Lab. Immunol. 7:131-140(2000) [PubMed] [Europe PMC] [Abstract]
  10. "Structural and functional properties of membrane and secreted IgD."Mol. Immunol. 37:871-887(2000) [PubMed] [Europe PMC] [Abstract]
  11. "The riddle of the dual expression of IgM and IgD."Immunology 118:429-437(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Amino acid sequence and location of the three glycopeptides in the Fc region of human immunoglobulin D."Biochem. Biophys. Res. Commun. 97:635-641(1980) [PubMed] [Europe PMC] [Abstract]
  13. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  14. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]