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Mothers Against Decapentaplegic Homolog 4 (Smad4)

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DPC4; JIP; MADH4; Deletion target in pancreatic carcinoma 4

Mothers Against Decapentaplegic Homolog 4 (Smad4)
CCC B925
HGNC 6770
MGI 894293
PubMed 12821112
RGD 3033
UniProt Q13485
Wiki SMAD4

SMAD4 is a 552 amino acid protein involved in cell signaling. It belongs to the Darfwin family of proteins which modulate members of the TGF beta protein superfamily. It binds receptor regulated SMADs such as SMAD1 or SMAD2 and forms a complex that binds to DNA and serves as a transcription factor. It is the only known mammalian coSMAD. It is a homolog of the Drosophila protein: "Mothers against decapentaplegic".
The SMAD proteins are homologs of both the drosophila protein, mothers against decapentaplegic (MAD) and the C. elegans protein SMA. The name is a combination of the two. During Drosophila research, it was found that a mutation in the gene, MAD, in the mother, repressed the gene, decapentaplegic, in the embryo.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB925Hu01 Recombinant Mothers Against Decapentaplegic Homolog 4 (Smad4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB925Hu01 Polyclonal Antibody to Mothers Against Decapentaplegic Homolog 4 (Smad4) WB; IHC; ICC; IP.
MAB925Hu22 Monoclonal Antibody to Mothers Against Decapentaplegic Homolog 4 (Smad4) WB; IHC; ICC; IP.
Assay Kits SEB925Hu ELISA Kit for Mothers Against Decapentaplegic Homolog 4 (Smad4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB925Mu01 Recombinant Mothers Against Decapentaplegic Homolog 4 (Smad4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB925Mu01 Polyclonal Antibody to Mothers Against Decapentaplegic Homolog 4 (Smad4) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Mothers Against Decapentaplegic Homolog 4 (Smad4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mothers Against Decapentaplegic Homolog 4 (Smad4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mothers Against Decapentaplegic Homolog 4 (Smad4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mothers Against Decapentaplegic Homolog 4 (Smad4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mothers Against Decapentaplegic Homolog 4 (Smad4) Polyclonal Antibody Customized Service Offer
Assay Kits SEB925Ra ELISA Kit for Mothers Against Decapentaplegic Homolog 4 (Smad4) Enzyme-linked immunosorbent assay for Antigen Detection.
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