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NADPH Oxidase 4 (NOX4)

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KOX; KOX-1; RENOX; Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4

NADPH Oxidase 4 (NOX4)
CCC B924
HGNC 7891
MGI 1354184
PubMed 16324151
RGD 620600
UniProt Q9NPH5
Wiki NOX4

Nicotinamide adenine dinucleotide phosphate-oxidase(NOX4 )is a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS).

The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants.
 

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB924Hu01 Recombinant NADPH Oxidase 4 (NOX4) Positive Control; Immunogen; SDS-PAGE; WB.
RPB924Hu02 Recombinant NADPH Oxidase 4 (NOX4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB924Hu01 Polyclonal Antibody to NADPH Oxidase 4 (NOX4) WB; IHC; ICC; IP.
MAB924Hu22 Monoclonal Antibody to NADPH Oxidase 4 (NOX4) WB; IHC; ICC; IP.
LAB924Hu71 Biotin-Linked Polyclonal Antibody to NADPH Oxidase 4 (NOX4) WB; IHC; ICC.
PAB924Hu02 Polyclonal Antibody to NADPH Oxidase 4 (NOX4) WB; IHC; ICC; IP.
Assay Kits SEB924Hu ELISA Kit for NADPH Oxidase 4 (NOX4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB924Mu01 Recombinant NADPH Oxidase 4 (NOX4) Positive Control; Immunogen; SDS-PAGE; WB.
RPB924Mu02 Recombinant NADPH Oxidase 4 (NOX4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB924Mu01 Polyclonal Antibody to NADPH Oxidase 4 (NOX4) WB; IHC; ICC; IP.
PAB924Mu02 Polyclonal Antibody to NADPH Oxidase 4 (NOX4) WB; IHC; ICC; IP.
Assay Kits SEB924Mu ELISA Kit for NADPH Oxidase 4 (NOX4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB924Ra01 Recombinant NADPH Oxidase 4 (NOX4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB924Ra01 Polyclonal Antibody to NADPH Oxidase 4 (NOX4) WB; IHC; ICC; IP.
MAB924Ra21 Monoclonal Antibody to NADPH Oxidase 4 (NOX4) WB; IHC; ICC; IP.
Assay Kits SEB924Ra ELISA Kit for NADPH Oxidase 4 (NOX4) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Identification of renox, an NAD(P)H oxidase in kidney."Proc. Natl. Acad. Sci. U.S.A. 97:8010-8014(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5."Gene 269:131-140(2001) [PubMed] [Europe PMC] [Abstract]
  3. "A novel superoxide-producing NAD(P)H oxidase in kidney."J. Biol. Chem. 276:1417-1423(2001) [PubMed] [Europe PMC] [Abstract]
  4. "NADPH oxidase-dependent acid production in airway epithelial cells."J. Biol. Chem. 279:36454-36461(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Identification of novel Nox4 splice variants with impact on ROS levels in A549 cells."Biochem. Biophys. Res. Commun. 329:32-39(2005) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Reactive oxygen species produced by NAD(P)H oxidase inhibit apoptosis in pancreatic cancer cells."J. Biol. Chem. 279:34643-34654(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Direct interaction of TLR4 with NAD(P)H oxidase 4 isozyme is essential for lipopolysaccharide-induced production of reactive oxygen species and activation of NF-kappa B."J. Immunol. 173:3589-3593(2004) [PubMed] [Europe PMC] [Abstract]
  11. "The NAD(P)H oxidase homolog Nox4 modulates insulin-stimulated generation of H2O2 and plays an integral role in insulin signal transduction."Mol. Cell. Biol. 24:1844-1854(2004) [PubMed] [Europe PMC] [Abstract]
  12. "NAD(P)H oxidase Nox-4 mediates 7-ketocholesterol-induced endoplasmic reticulum stress and apoptosis in human aortic smooth muscle cells."Mol. Cell. Biol. 24:10703-10717(2004) [PubMed] [Europe PMC] [Abstract]
  13. "Nox4 is critical for hypoxia-inducible factor 2-alpha transcriptional activity in von Hippel-Lindau-deficient renal cell carcinoma."Cancer Res. 65:9190-9193(2005) [PubMed] [Europe PMC] [Abstract]
  14. "NAD(P)H oxidase 4 mediates transforming growth factor-beta1-induced differentiation of cardiac fibroblasts into myofibroblasts."Circ. Res. 97:900-907(2005) [PubMed] [Europe PMC] [Abstract]
  15. "The superoxide-producing NAD(P)H oxidase Nox4 in the nucleus of human vascular endothelial cells."Genes Cells 10:1139-1151(2005) [PubMed] [Europe PMC] [Abstract]
  16. "Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases."Cell. Signal. 18:69-82(2006) [PubMed] [Europe PMC] [Abstract]
  17. "NOX4 as an oxygen sensor to regulate TASK-1 activity."Cell. Signal. 18:499-507(2006) [PubMed] [Europe PMC] [Abstract]
  18. "A 28-kDa splice variant of NADPH oxidase-4 is nuclear-localized and involved in redox signaling in vascular cells."Arterioscler. Thromb. Vasc. Biol. 33:E104-E112(2013) [PubMed] [Europe PMC] [Abstract]