≡

Chemokine C-C-Motif Receptor 4 (CCR4)

[Edit]

CD194; CC-CKR-4; CKR4; CMKBR4; ChemR13; K5-5

Chemokine C-C-Motif Receptor 4 (CCR4)
CCC B920
HGNC 1605
MGI 107824
PubMed 19630858
RGD 620594
UniProt P51679
Wiki CCR4

Chemokine (C-C motif) receptor 4, is a protein belongs to the G protein-coupled receptor family. It is a receptor for the following CC chemokines: CCL2 (MCP-1) ;CCL4 (MIP-1) ;CCL5 (RANTES) ;CCL17 (TARC);CCL22 (Macrophage-derived chemokine)
As Th2 type lymphocytes orchestrate the cardinal features of allergic asthma, inhibiting their recruitment to the lungs could be of therapeutic benefit. Although human Th2 cells express the CCR4 chemokine receptor and increased production of CCR4 ligands has been found in asthmatic airways, studies in animals have reached contradictory conclusions on whether blocking this pathway would be beneficial.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB920Hu01 Recombinant Chemokine C-C-Motif Receptor 4 (CCR4) Positive Control; Immunogen; SDS-PAGE; WB.
RPB920Hu02 Recombinant Chemokine C-C-Motif Receptor 4 (CCR4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB920Hu01 Polyclonal Antibody to Chemokine C-C-Motif Receptor 4 (CCR4) WB; IHC; ICC; IP.
MAB920Hu21 Monoclonal Antibody to Chemokine C-C-Motif Receptor 4 (CCR4) WB; IHC; ICC; IP.
Assay Kits SEB920Hu ELISA Kit for Chemokine C-C-Motif Receptor 4 (CCR4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chemokine C-C-Motif Receptor 4 (CCR4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chemokine C-C-Motif Receptor 4 (CCR4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chemokine C-C-Motif Receptor 4 (CCR4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chemokine C-C-Motif Receptor 4 (CCR4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chemokine C-C-Motif Receptor 4 (CCR4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chemokine C-C-Motif Receptor 4 (CCR4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chemokine C-C-Motif Receptor 4 (CCR4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chemokine C-C-Motif Receptor 4 (CCR4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chemokine C-C-Motif Receptor 4 (CCR4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chemokine C-C-Motif Receptor 4 (CCR4) ELISA Kit Customized Service Offer
  1. "Molecular cloning and functional expression of a novel CC chemokine receptor cDNA from a human basophilic cell line."J. Biol. Chem. 270:19495-19500(1995) [PubMed] [Europe PMC] [Abstract]
  2. "New variations of human CC-chemokine receptors CCR3 and CCR4."Genes Immun. 1:97-104(1999) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4."J. Biol. Chem. 272:15036-15042(1997) [PubMed] [Europe PMC] [Abstract]
  5. "Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4."J. Biol. Chem. 273:1764-1768(1998) [PubMed] [Europe PMC] [Abstract]
  6. "The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells."Nature 400:776-780(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Human NK cells express CC chemokine receptors 4 and 8 and respond to thymus and activation-regulated chemokine, macrophage-derived chemokine, and I-309."J. Immunol. 164:4048-4054(2000) [PubMed] [Europe PMC] [Abstract]
  8. "Chemokine-like factor 1 is a functional ligand for CC chemokine receptor 4 (CCR4)."Life Sci. 78:614-621(2006) [PubMed] [Europe PMC] [Abstract]