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Phosphatidylserine Receptor (PSR)

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JMJD6; PTDSR; Jumonji Domain Containing 6; JmjC domain-containing protein 6; Bifunctional Arginine Demethylase And Lysyl-Hydroxylase; Peptide-lysine 5-dioxygenase JMJD6

Phosphatidylserine Receptor (PSR)
CCC B916
HGNC 19355
MGI 1858910
PubMed 14645847
RGD 1305395
UniProt Q6NYC1
Wiki JMJD6

Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 is a nuclear protein with a JmjC domain. JmjC domain-containing proteins are predicted to function as protein hydroxylases or histone demethylases.

This protein was first identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells; however, subsequent studies have suggested that the protein may cross-react with a monoclonal antibody that recognizes the phosphatidylserine receptor and does not directly function in the clearance of apoptotic cells. Multiple transcript variants encoding different isoforms have been found for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB916Hu01 Recombinant Phosphatidylserine Receptor (PSR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB916Hu01 Polyclonal Antibody to Phosphatidylserine Receptor (PSR) WB
Assay Kits n/a CLIA Kit for Phosphatidylserine Receptor (PSR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphatidylserine Receptor (PSR) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphatidylserine Receptor (PSR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphatidylserine Receptor (PSR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphatidylserine Receptor (PSR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphatidylserine Receptor (PSR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphatidylserine Receptor (PSR) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphatidylserine Receptor (PSR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphatidylserine Receptor (PSR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphatidylserine Receptor (PSR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphatidylserine Receptor (PSR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphatidylserine Receptor (PSR) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
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  5. "Nuclear localization of the phosphatidylserine receptor protein via multiple nuclear localization signals."Exp. Cell Res. 293:154-163(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Phosphatidylserine receptor cooperates with high-density lipoprotein receptor in recognition of apoptotic cells by thymic nurse cells."J. Mol. Endocrinol. 32:497-505(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Phosphatidylserine receptor in chronic pancreatitis: evidence for a macrophage independent role."Ann. Surg. 241:144-151(2005) [PubMed] [Europe PMC] [Abstract]
  8. "JMJD6 is a histone arginine demethylase."Science 318:444-447(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing."Science 325:90-93(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Analysis of Jmjd6 cellular localization and testing for its involvement in histone demethylation."PLoS ONE 5:E13769-E13769(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3."Mol. Cell. Biol. 31:2641-2652(2011) [PubMed] [Europe PMC] [Abstract]
  13. "Crystal structure of the 2-oxoglutarate- and Fe(II)-dependent lysyl hydroxylase JMJD6."J. Mol. Biol. 401:211-222(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Interaction of JMJD6 with single-stranded RNA."Proc. Natl. Acad. Sci. U.S.A. 107:14568-14572(2010) [PubMed] [Europe PMC] [Abstract]