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Glycoprotein VI (GP6)

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GPIV; GP-VI; Glycoprotein VI, Platelet

Glycoprotein VI (GP6)
CCC B904
HGNC 14388
MGI 1889810
PubMed 19065783
UniProt Q9HCN6
Wiki GPVI

Glycoprotein VI (GP6) is a 58-kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. Upon injury to the vessel wall and subsequent damage to the endothelial lining, exposure of the subendothelial matrix to blood flow results in deposition of platelets. Collagen fibers are the most thrombogenic macromolecular components of the extracellular matrix, with collagen types I, III, and VI being the major forms found in blood vessels. Platelet interaction with collagen occurs as a 2-step procedure: (1) the initial adhesion to collagen is followed by (2) an activation step leading to platelet secretion, recruitment of additional platelets, and aggregation. In physiologic conditions, the resulting platelet plug is the initial hemostatic event limiting blood loss.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB904Hu01 Recombinant Glycoprotein VI (GP6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB904Hu01 Polyclonal Antibody to Glycoprotein VI (GP6) WB; IHC
MAB904Hu22 Monoclonal Antibody to Glycoprotein VI (GP6) WB; IHC; ICC; IP.
LAB904Hu71 Biotin-Linked Polyclonal Antibody to Glycoprotein VI (GP6) WB; IHC; ICC.
Assay Kits SEB904Hu ELISA Kit for Glycoprotein VI (GP6) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glycoprotein VI (GP6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Glycoprotein VI (GP6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glycoprotein VI (GP6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Glycoprotein VI (GP6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glycoprotein VI (GP6) ELISA Kit Customized Service Offer
  1. "Molecular cloning, genomic structure, chromosomal localization, and alternative splice forms of the platelet collagen receptor glycoprotein VI."Biochem. Biophys. Res. Commun. 277:27-36(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily."Blood 96:1798-1807(2000) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "A novel association of Fc receptor gamma-chain with glycoprotein VI and their co-expression as a collagen receptor in human platelets."J. Biol. Chem. 272:23528-23531(1997) [PubMed] [Europe PMC] [Abstract]
  6. "The influence of N-linked glycosylation on the function of platelet glycoprotein VI."Blood 106:2744-2749(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Gain- and loss-of-function mutants confirm the importance of apical residues to the primary interaction of human glycoprotein VI with collagen."J. Thromb. Haemost. 4:869-873(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Structural basis for platelet collagen responses by the immune-type receptor glycoprotein VI."Blood 108:936-942(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Absence of collagen-induced platelet activation caused by compound heterozygous GPVI mutations."Blood 114:1900-1903(2009) [PubMed] [Europe PMC] [Abstract]
  10. "A compound heterozygous mutation in glycoprotein VI in a patient with a bleeding disorder."J. Thromb. Haemost. 7:1356-1363(2009) [PubMed] [Europe PMC] [Abstract]