Apolipoprotein C3 (APOC3)

Apolipoprotein C-III is a very low density lipoprotein (VLDL) protein. APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed.

An increase in apoC-III levels induces the development of hypertriglyceridemia.Lately, two novel susceptibility haplotypes i.e. P2-S2-X1 and P1-S2-X1 have been discovered in ApoAI-CIII-AIV gene cluster on chromosme 11q23, who confer approximately threefold higher risk of coronary heart disease in normal as well as non-insulin diabetes mellitus.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB890Hu01 Recombinant Apolipoprotein C3 (APOC3) Positive Control; Immunogen; SDS-PAGE; WB.
APB890Hu01 Active Apolipoprotein C3 (APOC3) Cell culture; Activity Assays.
RPB890Hu02 Recombinant Apolipoprotein C3 (APOC3) Positive Control; Immunogen; SDS-PAGE; WB.
RPB890Hu03 Recombinant Apolipoprotein C3 (APOC3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB890Hu01 Polyclonal Antibody to Apolipoprotein C3 (APOC3) WB; ICC; IHC-P; IHC-F; ELISA.
MAB890Hu22 Monoclonal Antibody to Apolipoprotein C3 (APOC3) WB; IHC; ICC; IP.
Assay Kits SEB890Hu ELISA Kit for Apolipoprotein C3 (APOC3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB890Mu01 Recombinant Apolipoprotein C3 (APOC3) Positive Control; Immunogen; SDS-PAGE; WB.
RPB890Mu02 Recombinant Apolipoprotein C3 (APOC3) Positive Control; Immunogen; SDS-PAGE; WB.
APB890Mu01 Active Apolipoprotein C3 (APOC3) Cell culture; Activity Assays.
Antibodies PAB890Mu01 Polyclonal Antibody to Apolipoprotein C3 (APOC3) WB; IHC; ICC; IP.
PAB890Mu02 Polyclonal Antibody to Apolipoprotein C3 (APOC3) WB; IHC; ICC; IP.
MAB890Mu21 Monoclonal Antibody to Apolipoprotein C3 (APOC3) WB; IHC; ICC; IP.
Assay Kits SEB890Mu ELISA Kit for Apolipoprotein C3 (APOC3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB890Ra01 Recombinant Apolipoprotein C3 (APOC3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB890Ra01 Polyclonal Antibody to Apolipoprotein C3 (APOC3) WB; IHC; ICC; IP.
LAB890Ra71 Biotin-Linked Polyclonal Antibody to Apolipoprotein C3 (APOC3) WB; IHC; ICC.
LAB890Ra81 FITC-Linked Polyclonal Antibody to Apolipoprotein C3 (APOC3) WB; IHC; ICC; IF.
MAB890Ra21 Monoclonal Antibody to Apolipoprotein C3 (APOC3) WB; IHC; ICC; IP.
Assay Kits SEB890Ra ELISA Kit for Apolipoprotein C3 (APOC3) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Isolation and sequence analysis of the human apolipoprotein CIII gene and the intergenic region between the apo AI and apo CIII genes."DNA 3:449-456(1984) [PubMed] [Europe PMC] [Abstract]
  2. "Isolation and DNA sequence of full-length cDNA for human preapolipoprotein CIII."DNA 3:359-364(1984) [PubMed] [Europe PMC] [Abstract]
  3. "Isolation and characterization of cDNA clones corresponding to two different human apoC-III alleles."J. Lipid Res. 26:451-456(1985) [PubMed] [Europe PMC] [Abstract]
  4. "Human apolipoproteins AI, AII, CII and CIII. cDNA sequences and mRNA abundance."Nucleic Acids Res. 12:3917-3932(1984) [PubMed] [Europe PMC] [Abstract]
  5. "The effects of scale: variation in the APOA1/C3/A4/A5 gene cluster."Hum. Genet. 115:36-56(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Amino acid sequence of human plasma apolipoprotein C-III from normolipidemic subjects."FEBS Lett. 197:67-73(1986) [PubMed] [Europe PMC] [Abstract]
  8. "The complete amino acid sequence of alanine apolipoprotein (apoC-3), and apolipoprotein from human plasma very low density lipoproteins."J. Biol. Chem. 249:4975-4984(1974) [PubMed] [Europe PMC] [Abstract]
  9. "An ABC of apolipoprotein C-III: a clinically useful new cardiovascular risk factor?"Int. J. Clin. Pract. 62:799-809(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Enrichment of glycopeptides for glycan structure and attachment site identification."Nat. Methods 6:809-811(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Apolipoprotein C-III and hepatic triglyceride-rich lipoprotein production."Curr. Opin. Lipidol. 23:206-212(2012) [PubMed] [Europe PMC] [Abstract]
  13. "Identification of new apolipoprotein-CIII glycoforms with ultrahigh resolution MALDI-FTICR mass spectrometry of human sera."J. Proteome Res. 12:2260-2268(2013) [PubMed] [Europe PMC] [Abstract]
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  15. "Molecular cloning of a human apoC-III variant: Thr 74-->Ala 74 mutation prevents O-glycosylation."J. Lipid Res. 28:1405-1409(1987) [PubMed] [Europe PMC] [Abstract]
  16. "Apolipoprotein C-III(Lys-58-->Glu). Identification of an apolipoprotein C-III variant in a family with hyperalphalipoproteinemia."J. Clin. Invest. 87:1724-1731(1991) [PubMed] [Europe PMC] [Abstract]