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Cyclin Dependent Kinase 7 (CDK7)

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CAK1; CDKN7; STK1; MO15; 39 kDa protein kinase; Serine/threonine-protein kinase 1; Cell Division Protein Kinase 7; TFIIH basal transcription factor complex kinase subunit

Cyclin Dependent Kinase 7 (CDK7)
CCC B880
HGNC 1778
MGI 102956
PubMed 15530371
RGD 621124
UniProt P50613
Wiki CDK7

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB880Hu01 Recombinant Cyclin Dependent Kinase 7 (CDK7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB880Hu01 Polyclonal Antibody to Cyclin Dependent Kinase 7 (CDK7) WB; IHC; ICC; IP.
MAB880Hu22 Monoclonal Antibody to Cyclin Dependent Kinase 7 (CDK7) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cyclin Dependent Kinase 7 (CDK7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclin Dependent Kinase 7 (CDK7) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB880Mu01 Recombinant Cyclin Dependent Kinase 7 (CDK7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB880Mu01 Polyclonal Antibody to Cyclin Dependent Kinase 7 (CDK7) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cyclin Dependent Kinase 7 (CDK7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclin Dependent Kinase 7 (CDK7) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cyclin Dependent Kinase 7 (CDK7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cyclin Dependent Kinase 7 (CDK7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cyclin Dependent Kinase 7 (CDK7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cyclin Dependent Kinase 7 (CDK7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclin Dependent Kinase 7 (CDK7) ELISA Kit Customized Service Offer
  1. "Cell cycle analysis of the activity, subcellular localization, and subunit composition of human CAK (CDK-activating kinase)."J. Cell Biol. 127:467-478(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Two novel human serine/threonine kinases with homologies to the cell cycle regulating Xenopus MO15, and NIMA kinases: cloning and characterization of their expression pattern."Oncogene 9:1977-1988(1994) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning, expression and subcellular localization of the human homolog of p40MO15 catalytic subunit of cdk-activating kinase."Oncogene 9:3127-3138(1994) [PubMed] [Europe PMC] [Abstract]
  4. "Molecular cloning of the human CAK1 gene encoding a cyclin-dependent kinase-activating kinase."Oncogene 9:2089-2096(1994) [PubMed] [Europe PMC] [Abstract]
  5. "Human and Xenopus MO15 mRNA are highly conserved but show different patterns of expression in adult tissues."Oncol. Rep. 1:1269-1275(1994)
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase."Cell 78:713-724(1994) [PubMed] [Europe PMC] [Abstract]
  8. "p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner."Mol. Cell. Biol. 17:7220-7229(1997) [PubMed] [Europe PMC] [Abstract]
  9. "The molecular mechanism of mitotic inhibition of TFIIH is mediated by phosphorylation of CDK7."Genes Dev. 12:3541-3550(1998) [PubMed] [Europe PMC] [Abstract]
  10. "Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes."J. Biol. Chem. 273:34444-34453(1998) [PubMed] [Europe PMC] [Abstract]
  11. "Regulation of CAK kinase activity by p53."Oncogene 17:2733-2741(1998) [PubMed] [Europe PMC] [Abstract]
  12. "Reconstitution of the transcription factor TFIIH: assignment of functions for the three enzymatic subunits, XPB, XPD, and cdk7."Mol. Cell 3:87-95(1999) [PubMed] [Europe PMC] [Abstract]
  13. "The FBP interacting repressor targets TFIIH to inhibit activated transcription."Mol. Cell 5:331-341(2000) [PubMed] [Europe PMC] [Abstract]
  14. "Reciprocal activation by cyclin-dependent kinases 2 and 7 is directed by substrate specificity determinants outside the T loop."Mol. Cell. Biol. 21:88-99(2001) [PubMed] [Europe PMC] [Abstract]
  15. "Cyclin-dependent kinase activating kinase/Cdk7 co-localizes with PKC-iota in human glioma cells."Tissue Cell 37:53-58(2005) [PubMed] [Europe PMC] [Abstract]
  16. "Dichotomous but stringent substrate selection by the dual-function Cdk7 complex revealed by chemical genetics."Nat. Struct. Mol. Biol. 13:55-62(2006) [PubMed] [Europe PMC] [Abstract]
  17. "Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells."Mol. Cell 25:839-850(2007) [PubMed] [Europe PMC] [Abstract]
  18. "Recognition of Cdk2 by Cdk7."Proteins 67:1048-1059(2007) [PubMed] [Europe PMC] [Abstract]
  19. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  20. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  21. "Phosphorylation of steroidogenic factor 1 is mediated by cyclin-dependent kinase 7."Mol. Endocrinol. 22:91-104(2008) [PubMed] [Europe PMC] [Abstract]
  22. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  23. "TFIIH kinase places bivalent marks on the carboxy-terminal domain of RNA polymerase II."Mol. Cell 34:387-393(2009) [PubMed] [Europe PMC] [Abstract]
  24. "SUMOylation inhibits SF-1 activity by reducing CDK7-mediated serine 203 phosphorylation."Mol. Cell. Biol. 29:613-625(2009) [PubMed] [Europe PMC] [Abstract]
  25. "TFIIH-associated Cdk7 kinase functions in phosphorylation of C-terminal domain Ser7 residues, promoter-proximal pausing, and termination by RNA polymerase II."Mol. Cell. Biol. 29:5455-5464(2009) [PubMed] [Europe PMC] [Abstract]
  26. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  27. "Binding to DNA of the RNA-polymerase II C-terminal domain allows discrimination between Cdk7 and Cdk9 phosphorylation."Nucleic Acids Res. 37:1260-1268(2009) [PubMed] [Europe PMC] [Abstract]
  28. "DNA-Bound peptides control the mRNA transcription through CDK7."Peptides 30:681-688(2009) [PubMed] [Europe PMC] [Abstract]
  29. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  30. "Cdc25 phosphatases are required for timely assembly of CDK1-cyclin B at the G2/M transition."J. Biol. Chem. 285:16978-16990(2010) [PubMed] [Europe PMC] [Abstract]
  31. "R-roscovitine (Seliciclib) affects CLL cells more strongly than combinations of fludarabine or cladribine with cyclophosphamide: Inhibition of CDK7 sensitizes leukemic cells to caspase-dependent apoptosis."J. Cell. Biochem. 109:217-235(2010) [PubMed] [Europe PMC] [Abstract]
  32. "CAK-Cyclin-dependent Activating Kinase: a key kinase in cell cycle control and a target for drugs?"Cell Cycle 4:572-577(2005) [PubMed] [Europe PMC] [Abstract]
  33. "Cell cycle, CDKs and cancer: a changing paradigm."Nat. Rev. Cancer 9:153-166(2009) [PubMed] [Europe PMC] [Abstract]
  34. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  35. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  36. "A history of TFIIH: Two decades of molecular biology on a pivotal transcription/repair factor."DNA Repair 10:714-721(2011) [PubMed] [Europe PMC] [Abstract]
  37. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  38. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  39. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  40. "The crystal structure of human CDK7 and its protein recognition properties."Structure 12:2067-2079(2004) [PubMed] [Europe PMC] [Abstract]
  41. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]