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Matrix Metalloproteinase 19 (MMP19)

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RASI-1; MMP18; Occasionally Referred To As Stromelysin-4

Matrix Metalloproteinase 19 (MMP19)
CCC B853
HGNC 7165
MGI 1927899
PubMed 15241558
RGD 1311376
UniProt Q99542
Wiki MMP19

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases.

Matrix metalloproteinase-19 is expressed in human epidermis and endothelial cells and it has a role in cellular proliferation, migration, angiogenesis and adhesion. Multiple transcript variants encoding distinct isoforms have been identified for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB853Hu01 Recombinant Matrix Metalloproteinase 19 (MMP19) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB853Hu01 Polyclonal Antibody to Matrix Metalloproteinase 19 (MMP19) WB; ICC; IHC-P; IHC-F; ELISA.
MAB853Hu22 Monoclonal Antibody to Matrix Metalloproteinase 19 (MMP19) WB; IHC; ICC; IP.
Assay Kits SEB853Hu ELISA Kit for Matrix Metalloproteinase 19 (MMP19) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB853Mu01 Recombinant Matrix Metalloproteinase 19 (MMP19) Positive Control; Immunogen; SDS-PAGE; WB.
RPB853Mu02 Recombinant Matrix Metalloproteinase 19 (MMP19) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB853Mu01 Polyclonal Antibody to Matrix Metalloproteinase 19 (MMP19) WB; IHC; ICC; IP.
PAB853Mu02 Polyclonal Antibody to Matrix Metalloproteinase 19 (MMP19) WB; IHC; ICC; IP.
Assay Kits SEB853Mu ELISA Kit for Matrix Metalloproteinase 19 (MMP19) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Matrix Metalloproteinase 19 (MMP19) Recombinant Protein Customized Service Offer
Antibodies PAB853Ra01 Polyclonal Antibody to Matrix Metalloproteinase 19 (MMP19) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Matrix Metalloproteinase 19 (MMP19) CLIA Kit Customized Service Offer
n/a ELISA Kit for Matrix Metalloproteinase 19 (MMP19) ELISA Kit Customized Service Offer
  1. "Identification of MMP-18, a putative novel human matrix metalloproteinase."Biochem. Biophys. Res. Commun. 228:494-498(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Identification and characterization of a novel human matrix metalloproteinase with unique structural characteristics, chromosomal location and tissue distribution."J. Biol. Chem. 272:4281-4286(1997) [PubMed] [Europe PMC] [Abstract]
  3. "The matrix metalloproteinase RASI-1 is expressed in synovial blood vessels of a rheumatoid arthritis patient."Immunol. Lett. 57:83-88(1997) [PubMed] [Europe PMC] [Abstract]
  4. "Matrix metalloproteinase MMP-19 (RASI-1) is expressed on the surface of activated peripheral blood mononuclear cells and is detected as an autoantigen in rheumatoid arthritis."Immunobiology 198:408-423(1998) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Biochemical characterization of the catalytic domain of human matrix metalloproteinase 19. Evidence for a role as a potent basement membrane degrading enzyme."J. Biol. Chem. 275:14809-14816(2000) [PubMed] [Europe PMC] [Abstract]
  9. "Matrix metalloproteinases 19 and 20 cleave aggrecan and cartilage oligomeric matrix protein (COMP)."FEBS Lett. 478:52-56(2000) [PubMed] [Europe PMC] [Abstract]
  10. "A secreted tyrosine kinase acts in the extracellular environment."Cell 158:1033-1044(2014) [PubMed] [Europe PMC] [Abstract]