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Beta-1,4-Galactosyltransferase 1 (b4GALT1)

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GTB; B4-GALT1; GGTB2; GT1; Beta4Gal-T1; Lactose Synthase A Protein; N-Acetyllactosamine Synthase; Nal synthase; beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1

Beta-1,4-Galactosyltransferase 1 (b4GALT1)
CCC B850
HGNC 924
MGI 95705
PubMed 23024026
RGD 620900
UniProt P15291
Wiki B4GALT1

Beta-1,4-galactosyltransferase 1 is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB850Hu01 Recombinant Beta-1,4-Galactosyltransferase 1 (b4GALT1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB850Hu01 Polyclonal Antibody to Beta-1,4-Galactosyltransferase 1 (b4GALT1) WB; IHC; ICC; IP.
MAB850Hu22 Monoclonal Antibody to Beta-1,4-Galactosyltransferase 1 (b4GALT1) WB; IHC; ICC; IP.
Assay Kits SEB850Hu ELISA Kit for Beta-1,4-Galactosyltransferase 1 (b4GALT1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Beta-1,4-Galactosyltransferase 1 (b4GALT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Beta-1,4-Galactosyltransferase 1 (b4GALT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Beta-1,4-Galactosyltransferase 1 (b4GALT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Beta-1,4-Galactosyltransferase 1 (b4GALT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Beta-1,4-Galactosyltransferase 1 (b4GALT1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Beta-1,4-Galactosyltransferase 1 (b4GALT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Beta-1,4-Galactosyltransferase 1 (b4GALT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Beta-1,4-Galactosyltransferase 1 (b4GALT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Beta-1,4-Galactosyltransferase 1 (b4GALT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Beta-1,4-Galactosyltransferase 1 (b4GALT1) ELISA Kit Customized Service Offer
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  10. "Isolation of galactosyltransferase from human milk and the determination of its N-terminal amino acid sequence."Biochem. Biophys. Res. Commun. 138:224-229(1986) [PubMed] [Europe PMC] [Abstract]
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  12. "Evidence for a molecular distinction between Golgi and cell surface forms of beta 1,4-galactosyltransferase."J. Biol. Chem. 266:15984-15991(1991) [PubMed] [Europe PMC] [Abstract]
  13. "Golgi retention mechanism of beta-1,4-galactosyltransferase. Membrane-spanning domain-dependent homodimerization and association with alpha- and beta-tubulins."J. Biol. Chem. 270:12170-12176(1995) [PubMed] [Europe PMC] [Abstract]
  14. "Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions."Biochim. Biophys. Acta 1473:35-53(1999) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  17. "Oligosaccharide preferences of beta1,4-galactosyltransferase-I: crystal structures of Met340His mutant of human beta1,4-galactosyltransferase-I with a pentasaccharide and trisaccharides of the N-glycan moiety."J. Mol. Biol. 353:53-67(2005) [PubMed] [Europe PMC] [Abstract]
  18. "Structural snapshots of beta-1,4-galactosyltransferase-I along the kinetic pathway."J. Mol. Biol. 357:1619-1633(2006) [PubMed] [Europe PMC] [Abstract]
  19. "Deoxygenated disaccharide analogs as specific inhibitors of beta1-4-galactosyltransferase 1 and selectin-mediated tumor metastasis."J. Biol. Chem. 284:4952-4959(2009) [PubMed] [Europe PMC] [Abstract]